Fig. 3

Metformin accelerated wound healing and stimulated angiogenesis in diabetic mice. Six-mm diameter wound was made by punch biopsy and closure of the wound area was measured every 2 days until day 10, metformin accelerated wound closure in STZ-induced diabetic mice (a, b). Typical photographs of CD31-positive staining on the wounded area were obtained on day 3, 6 and 9 (c, d). **P < 0.01, *P < 0.05 vs Control; ^# P < 0.05 vs STZ. Values are mean ± SEM (n = 5 per group)