Fig. 2

Establishment of STZ-induced diabetic mice. Compared with the control, mice treated with STZ (60 mg/kg/d × 5 d, i.p.) displayed higher blood glucose (a) and lower body weight (b). Metformin (250 mg/kg/d × 14 d, i.g.) decreased blood glucose (c), but did not change the body weight (d) in STZ-induced diabetic mice. **P < 0.01, *P < 0.05 vs Control; ^## P < 0.01 vs STZ. Values are mean ± SEM (n = 10 per group)