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Table 4 Diabetic patients stratified by statin use prior to first myocardial infarction

From: Statin use and cardiovascular risk factors in diabetic patients developing a first myocardial infarction

 

On statins before MI

Not on statins before MI

p value

n = 106

n = 122

Gender, %

0.51

Age, year

70.1 (12.0)

70.6 (15.2)

0.80

Smoking, %

34

37

0.21

Total cholesterol, mmol/L

4.1 (1.2)

4.8 (1.4)

<0.001

LDL cholesterol, mmol/L

2.1 (0.9)

2.9 (1.2)

<0.001

HDL cholesterol, mmol/L

1.2 (0.4)

1.2 (0.4)

0.42

Triglycerides, mmol/L

1.8 (1.6)

1.9 (1.3)

0.45

Systolic blood pressure, mmHg

139 (21.5)

138 (24.0)

0.76

Hypertension, %

89

71

0.001

Antihypertensive medicine, %

79

60

0.002

GFRc, mL/min/1.73 m2

64 (27.3)

72 (27.3)

0.03

Nephropathy (GFR < 60)c,  %

43

33

0.69

Family history of CHD,  %

37

34

0.62

LDL cholesterol ≥2 mmol/L,  %

54

81

<0.001

LDL cholesterol ≥1.8 mmol/L,  %

57

83

<0.001

SCORE (mean),  %

3.8 (2.8)

 

SCORE (mean) before statin therapya, %

4.6 (3.8)

 

Estimated 10-year risk in diabetes (mean)b,  %

16.6 (12.4)

13.7 (10.2)

0.10

Estimated 10-year risk in diabetes ≥5 %b, n/n

91 %

85 %

0.22

  1. Baseline characteristics are provided as mean (standard deviation) for continuous values
  2. aSCORE was calculated after adding 1.5 mmol/L to the measured on-treatment total cholesterol concentration (an estimate of the pre-treatment SCORE risk)
  3. bSCORE risk multiplied by 3 in men and 5 in women to take the diabetes-related risk into account [5, 6, 15]
  4. c GFR glomerular filtration rate; GFR < 60 mL/min/1.73 m2 is defined as moderate-to-severe chronic kidney disease in the ESC guideline [6]