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Table 2 Comparison of clinical and biochemical parameters at baseline and 24 weeks

From: Impact of teneligliptin on oxidative stress and endothelial function in type 2 diabetes patients with chronic kidney disease: a case–control study

  Teneligliptin (n = 22) Sitagliptin (n = 23) P1 value P2 value
Baseline 24 weeks Baseline 24 weeks
HbA1c % (NGSP) 8.1 ± 1.4 8.0 ± 1.2 8.0 ± 1.7 7.9 ± 1.4 0.27 0.39
Fasting glucose (mg/dL) 161.5 ± 49.7 157.7 ± 31.7 150.0 ± 26.3 161.7 ± 33.6 0.8 0.19
C-peptide (ng/mL) 1.8 ± 0.9 2.0 ± 0.6 2.5 ± 1.0 2.5 ± 1.1 0.32 0.33
SBP (mmHg) 133.3 ± 13.4 132.4 ± 14.2 139.1 ± 22.9 131.4 ± 16.8 0.79 0.06
DBP (mmHg) 76.1 ± 11.0 74.0 ± 10.9 79.3 ± 17.0 75.4 ± 12.8 0.5 0.07
LDL-C (mg/dL) 107.1 ± 21.3 105.3 ± 19.4 98.2 ± 21.5 98.7 ± 21.6 0.71 0.91
HDL-C (mg/dL) 53.4 ± 13.2 50.7 ± 12.0 55.5 ± 16.8 50.1 ± 9.1 0.12 0.06
TG (mg/dL) 120.3 ± 41.3 129.3 ± 60.1 156.1 ± 99.9 149.0 ± 70.2 0.51 0.61
eGFR (ml/min−1/1.73 m2) 43.5 ± 15.8 42.8 ± 16.7 39.6 ± 15.9 39.2 ± 16.2 0.36 0.77
Urinary albumin (mg/g Cre) 141.0 (93.5–299.5) 176.0 (84.5-268.0) 141.5 (67.0–729.3) 165.5 (52.8-546.0) 0.58 0.32
Log urinary albumin (mg/g Cre) 2.3 ± 0.5 2.3 ± 0.5 2.3 ± 0.6 2.3 ± 0.6 0.73 0.25
Urinary 8-OHdG (ng/mg Cre) 7.1 ± 4.9 5.4 ± 2.9 6.4 ± 1.5 7.4 ± 2.1 0.03* 0.1
Urinary L-FABP (µg/g Cre) 25.7 (6.3–118.0) 14.5 (7.0–64.9) 48.2 (7.2–91.9) 55.0 (9.6–110.8) 0.02* 0.22
Urinary 8-isoprostane (pg/mgCr) 199.0 (151.5–424.0) 297.0 (212.5–440.0) 258.0 (227.0–429.0) 353.0 (301.0–578.0) 0.06 0.01*
  1. Data are mean ± SD or median and interquartile range
  2. SBP systolic blood pressure, DBP diastolic blood pressure, LDL-C low-density lipoprotein cholesterol, HDL high-density lipoprotein cholesterol, TG triglycerides, eGER estimated glomerular filtration rate, 8-OHdG 8-hydroxy-2′-deoxyguanosine, L-FABP liver-type fatty acid binding protein
  3. * P1 value: <0.05, comparison of respective data between baseline and after 24 weeks treatment with teneligliptin
  4. * P2 value: <0.05, comparison of respective data between baseline and after 6 month treatment with sitagliptin