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Table 2 Multivariate regression analysis fo vascular reactivity

From: Impact of individual metabolic risk components or its clustering on endothelial and smooth muscle cell function in men

  Model 1a Model 2a Model 3a Model 4a Model 5a Model 6b
Ach-induced maximal forearm blood flow (FBF)
Corrected R2 0.228 0.347 0.514 0.297 0.429 0.522
P value 0.009 0.006 0.001 0.002 0.000 0.000
Variables E P E P E P E P E P E P
Age (years) −0.153 0.156 −0.018 0.868 0.085 0.427 −0.109 0.288 0.016 0.883 0 0.712
Current smoking (yes or no) 1.246 0.336 0.532 0.665 −0.770 0.517 0.188 0.876 −0.991 0.419 0 0.562
Waist circumference (cm) ≥85 cm (yes or no) 4.749 0.002 3.387 0.024 2.137 0.116      0 0.134
SBP ≥130 or DBP ≥85 mmHg or use of antihypertensive drugs    1.931 0.146 2.613 0.046      0 0.326
Glucose ≥100 mg/dL (yes or no)    1.947 0.131 −0.374 0.771      0 0.184
Triglycerides ≥150 mg/dL (yes or no)    2.230 0.095 1.305 0.298      0 0.490
HDL-cholesterol ≥150 mg/dL (yes or no)    1.065 0.456 1.493 0.286      0 0.965
Metabolic syndrome (yes or no)        4.675 0.000 −3.120 0.022 −3.560 0.006
M (mg/kg/min)      1.424 0.005    1.258 0.012 1.186 0.005
SNP-induced maximal forearm blood flow (FBF)
Corrected R2 0.123 0.117 0.148 0.173 0.224 0.254
P value 0.063 0.159 0.152 0.026 0.022 0.0017
Variables E P E P E P E P E P   
Age (years) −0.233 0.020 −0.153 0.168 −0.114 0.346 −0.213 0.029 −0.151 0.162 0 0.240
Current smoking (yes or no) 1.239 0.293 0.875 0.474 0.229 0.864 0.848 0.448 0.232 0.848 0 0.906
Waist circumference (cm) ≥85 cm (yes or no) 1.669 0.202 1.477 0.304 0.507 0.735      0 0.818
SBP ≥130 or DBP ≥85 mmHg or use of antihypertensive drugs    0.437 0.736 1.123 0.432      0 0.415
Glucose ≥100 mg/dL (yes or no)    2.355 0.069 0.649 0.655      0 0.438
Triglycerides ≥150 mg/dL (yes or no)    −0.091 0.944 −0.810 0.563      0 0.726
HDL-cholesterol ≥150 mg/dL (yes or no)    0.792 0.576 1.492 0.343      0 0.519
Metabolic syndrome (yes or no)        −2.120 0.061 −1.022 0.430 0 0.336
M (mg/kg/min)      0.872 0.107    0.784 0.103 1.237 0.002
∆Ach-induced maximal forearm blood flow (FBF) by L-NMMA
Corrected R2 0.236 0.460 0.594 0.406 0.533 0.481
P value 0.009 0.001 0.000 0.000 <0.0001 <0.0001
Variables E P E P E P E P E P E P
Age (years) −0.179 0.029 −0.071 0.344 −0.013 0.866 −0.145 0.045 0.074 0.415 0 0.094
Current smoking (yes or no) 0.635 0.512 −0.007 0.993 −0.726 0.397 −0.069 0.935 0.854 0.407 0 0.558
Waist circumference (cm) ≥85 cm (yes or no) 3.048 0.008 1.975 0.068 1.112 0.265      0 0.918
SBP ≥130 or DBP ≥85 mmHg or use of antihypertensive drugs    1.874 0.049 2.161 0.028      0 0.216
Glucose ≥100 mg/dL (yes or no)    1.541 0.085 0.141 0.877      0 0.594
Triglycerides ≥150 mg/dL (yes or no)    1.731 0.073 1.403 0.131      0 0.360
HDL-cholesterol ≥150 mg/dL (yes or no)    1.673 0.100 1.856 0.075      0 0.774
Metabolic syndrome (yes or no)        −3.627 0.000 0.950 0.008 −15.01 0.000
M (mg/kg/min)      0.867 0.015    0.341 0.021 0 0.112
  1. aModel 1–5: standard multiple regression analysis
  2. bModel 6: stepwise multiple regression analysis