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Table 4 Distribution of anthropometric and biological variables according to birth weight, women, multivariate adjusted

From: Low birth weight leads to obesity, diabetes and increased leptin levels in adults: the CoLaus study

 

Birth weight categories (kg)

p value

Linear

Quadratic

−2.5] (n = 174)

]2.5–3.5] (n = 891)

]3.5–4.0] (n = 264)

]4.0+ (n = 129)

Anthropometrya

 Height (cm)

161 ± 1

164 ± 1

165 ± 1

166 ± 1

<0.001

<0.001

0.069

 Weight (kg)

64.5 ± 1

64.7 ± 0.4

69.2 ± 0.8

69.8 ± 1.1

<0.001

<0.001

0.797

 BMI (kg/m2)

24.8 ± 0.4

24.1 ± 0.2

25.4 ± 0.3

25.4 ± 0.4

<0.001

0.086

0.285

 Waist circumference (cm)

83.1 ± 0.9

81.0.0 ± 0.4

83.5 ± 0.7

83.9 ± 1.1

0.002

0.259

0.125

 Fat (% of body weight)

33.8 ± 0.6

32.5 ± 0.2

33.6 ± 0.5

33.2 ± 0.6

0.061

0.861

0.421

 Fat mass (kg)

22.4 ± 0.7

21.6 ± 0.3

24.1 ± 0.6

23.8 ± 0.8

<0.001

0.033

0.692

 Normal weight

0.70 (0.50–0.98)

1 (ref.)

0.66 (0.50–0.88)

0.59 (0.40–0.86)

 

0.197

0.089

 Abdominal obesity

1.35 (0.94–1.94)

1 (ref.)

1.40 (1.03–1.90)

1.67 (1.12–2.49)

0.206

0.106

Adipokines

 Leptin (ng/dL)a

17.8 ± 0.9

15.5 ± 0.4

16.9 ± 0.7

16.0 ± 1.1

0.357§

0.337§

0.522§

 Leptin (ng/dL)b

16.9 ± 0.6

16.3 ± 0.3

15.8 ± 0.5

13.8 ± 0.8

0.008§

0.004§

0.241§

 Leptin (ng/dL)c

16.7 ± 0.7

16.1 ± 0.3

16.1 ± 0.6

14.4 ± 0.8

0.147§

0.050§

0.341§

 Leptin (ng/dL)d

17.3 ± 0.7

16.2 ± 0.3

15.6 ± 0.5

14.0 ± 0.8

0.012§

0.003§

0.541§

 Leptin/fat mass ratiob

0.77 ± 0.04

0.73 ± 0.02

0.69 ± 0.03

0.62 ± 0.04

0.029

0.004

0.655

 Adiponectin (µg/dL)a

11.6 ± 0.7

12.3 ± 0.3

11.9 ± 0.5

12.2 ± 0.8

0.560§

0.244

0.867

 Adiponectin (µg/dL)b

11.8 ± 0.7

12.1 ± 0.3

12.2 ± 0.5

12.5 ± 0.8

0.433§

0.105§

0.796§

 Adiponectin (µg/dL)c

11.9 ± 0.7

12.1 ± 0.3

12.2 ± 0.5

12.5 ± 0.8

0.594§

0.150§

0.800§

 Adiponectin (µg/dL)d

11.7 ± 0.6

12.1 ± 0.3

12.2 ± 0.5

12.5 ± 0.8

0.406§

0.090§

0.970§

Markers of glucose homeostasis

 Fasting Glucose (mmol/L)b, e

5.37 ± 0.05

5.28 ± 0.02

5.26 ± 0.04

5.18 ± 0.06

0.115

0.016

0.903

 Fasting Insulin (μU/mL)b, e

8.2 ± 0.4

7.5 ± 0.2

8.0 ± 0.3

6.5 ± 0.4

0.012

0.008

0.194

 HOMAb, e

1.99 ± 0.1

1.83 ± 0.04

1.95 ± 0.08

1.50 ± 0.12

0.006

0.004

0.106

 Diabetesb

2.43 (1.02–5.79)

1 (ref.)

0.75 (0.27–2.12)

1.40 (0.50–3.98)

0.285

0.053

 Diabetesc

2.38 (0.97–5.84)

1 (ref.)

0.89 (0.32–2.48)

1.86 (0.65–5.29)

0.634

0.042

 Diabetesd

2.70 (1.13–6.45)

1 (ref.)

0.71 (0.25–2.03)

1.17 (0.38–3.55)

0.134

0.067

 High HOMAb

1.32 (0.83–2.12)

1 (ref.)

0.81 (0.51–1.28)

0.63 (0.33–1.19)

0.031

0.947

 Metabolic syndromea

1.75 (1.15–2.68)

1 (ref.)

1.12 (0.74–1.69)

1.05 (0.62–1.79)

0.140

0.195

  1. Results are expressed as adjusted mean ± standard error or as odds ratio and (95 % confidence interval). Normal weight was defined as a body mass index <25 kg/m2; abdominal obesity was defined as a waist circumference ≥88 cm for women and ≥102 cm in men. Statistical analysis conducted using analysis of variance for continuous variables and logistic regression for categorical variables. Statistically significant odds ratios are indicated in italics. Column p value corresponds to the p value of the overall association test; column linear trend corresponds to the p value for testing a linear trend. Adjusted for: a age, smoking status and physical activity; b age, smoking status, physical activity and BMI; c age, smoking status, physical activity and waist circumference; d age, smoking status, physical activity and fat mass. Also adjusted for e antidiabetic drug treatment
  2. §Statistical analysis performed on log-transformed data