From: Low birth weight leads to obesity, diabetes and increased leptin levels in adults: the CoLaus study
Birth weight categories (kg) | p value | Linear | Quadratic | ||||
---|---|---|---|---|---|---|---|
−2.5] (n = 174) | ]2.5–3.5] (n = 891) | ]3.5–4.0] (n = 264) | ]4.0+ (n = 129) | ||||
Anthropometrya | |||||||
Height (cm) | 161 ± 1 | 164 ± 1 | 165 ± 1 | 166 ± 1 | <0.001 | <0.001 | 0.069 |
Weight (kg) | 64.5 ± 1 | 64.7 ± 0.4 | 69.2 ± 0.8 | 69.8 ± 1.1 | <0.001 | <0.001 | 0.797 |
BMI (kg/m2) | 24.8 ± 0.4 | 24.1 ± 0.2 | 25.4 ± 0.3 | 25.4 ± 0.4 | <0.001 | 0.086 | 0.285 |
Waist circumference (cm) | 83.1 ± 0.9 | 81.0.0 ± 0.4 | 83.5 ± 0.7 | 83.9 ± 1.1 | 0.002 | 0.259 | 0.125 |
Fat (% of body weight) | 33.8 ± 0.6 | 32.5 ± 0.2 | 33.6 ± 0.5 | 33.2 ± 0.6 | 0.061 | 0.861 | 0.421 |
Fat mass (kg) | 22.4 ± 0.7 | 21.6 ± 0.3 | 24.1 ± 0.6 | 23.8 ± 0.8 | <0.001 | 0.033 | 0.692 |
Normal weight | 0.70 (0.50–0.98) | 1 (ref.) | 0.66 (0.50–0.88) | 0.59 (0.40–0.86) | 0.197 | 0.089 | |
Abdominal obesity | 1.35 (0.94–1.94) | 1 (ref.) | 1.40 (1.03–1.90) | 1.67 (1.12–2.49) | – | 0.206 | 0.106 |
Adipokines | |||||||
Leptin (ng/dL)a | 17.8 ± 0.9 | 15.5 ± 0.4 | 16.9 ± 0.7 | 16.0 ± 1.1 | 0.357§ | 0.337§ | 0.522§ |
Leptin (ng/dL)b | 16.9 ± 0.6 | 16.3 ± 0.3 | 15.8 ± 0.5 | 13.8 ± 0.8 | 0.008§ | 0.004§ | 0.241§ |
Leptin (ng/dL)c | 16.7 ± 0.7 | 16.1 ± 0.3 | 16.1 ± 0.6 | 14.4 ± 0.8 | 0.147§ | 0.050§ | 0.341§ |
Leptin (ng/dL)d | 17.3 ± 0.7 | 16.2 ± 0.3 | 15.6 ± 0.5 | 14.0 ± 0.8 | 0.012§ | 0.003§ | 0.541§ |
Leptin/fat mass ratiob | 0.77 ± 0.04 | 0.73 ± 0.02 | 0.69 ± 0.03 | 0.62 ± 0.04 | 0.029 | 0.004 | 0.655 |
Adiponectin (µg/dL)a | 11.6 ± 0.7 | 12.3 ± 0.3 | 11.9 ± 0.5 | 12.2 ± 0.8 | 0.560§ | 0.244 | 0.867 |
Adiponectin (µg/dL)b | 11.8 ± 0.7 | 12.1 ± 0.3 | 12.2 ± 0.5 | 12.5 ± 0.8 | 0.433§ | 0.105§ | 0.796§ |
Adiponectin (µg/dL)c | 11.9 ± 0.7 | 12.1 ± 0.3 | 12.2 ± 0.5 | 12.5 ± 0.8 | 0.594§ | 0.150§ | 0.800§ |
Adiponectin (µg/dL)d | 11.7 ± 0.6 | 12.1 ± 0.3 | 12.2 ± 0.5 | 12.5 ± 0.8 | 0.406§ | 0.090§ | 0.970§ |
Markers of glucose homeostasis | |||||||
Fasting Glucose (mmol/L)b, e | 5.37 ± 0.05 | 5.28 ± 0.02 | 5.26 ± 0.04 | 5.18 ± 0.06 | 0.115 | 0.016 | 0.903 |
Fasting Insulin (μU/mL)b, e | 8.2 ± 0.4 | 7.5 ± 0.2 | 8.0 ± 0.3 | 6.5 ± 0.4 | 0.012 | 0.008 | 0.194 |
HOMAb, e | 1.99 ± 0.1 | 1.83 ± 0.04 | 1.95 ± 0.08 | 1.50 ± 0.12 | 0.006 | 0.004 | 0.106 |
Diabetesb | 2.43 (1.02–5.79) | 1 (ref.) | 0.75 (0.27–2.12) | 1.40 (0.50–3.98) | – | 0.285 | 0.053 |
Diabetesc | 2.38 (0.97–5.84) | 1 (ref.) | 0.89 (0.32–2.48) | 1.86 (0.65–5.29) | – | 0.634 | 0.042 |
Diabetesd | 2.70 (1.13–6.45) | 1 (ref.) | 0.71 (0.25–2.03) | 1.17 (0.38–3.55) | – | 0.134 | 0.067 |
High HOMAb | 1.32 (0.83–2.12) | 1 (ref.) | 0.81 (0.51–1.28) | 0.63 (0.33–1.19) | – | 0.031 | 0.947 |
Metabolic syndromea | 1.75 (1.15–2.68) | 1 (ref.) | 1.12 (0.74–1.69) | 1.05 (0.62–1.79) | – | 0.140 | 0.195 |