Fig. 5
Zn(ASA)2 decreases cardiomyocyte hypertrophy and nitro-oxidative stress. a Hematoxylin and eosin staining micrographs of transverse sections of myocardium (magnification ×400; scale bar: 50 μm) and representative photomicrographs of nitrotyrosine immunohistochemistry staining; magnification ×200, scale bar: 20 µm. b Quantitative analysis of cardiomyocyte cross-sectional area using of ~20 cardiomyocytes in each group and c immunohistochemical scores for nitrotyrosine in the myocardium. Values are mean ± SEM, n = 6–9. *P < 0.05 vs ZL, #P < 0.05 vs ZDF, $P < 0.05 vs Zn(ASA)2. Zn(ASA) 2 indicates a zinc complex of acetylsalicylic acid, ZDF Zucker diabetic fatty rats, ZL Zucker lean