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Table 1 Body weight and fasting blood glucose in CON, CON +100 mg/kg/day berberine, diabetic, and diabetic +100 mg/kg/day berberine rats at 4 and 8 weeks after STZ-injection in Experiment I

From: Berberine alleviates the cerebrovascular contractility in streptozotocin-induced diabetic rats through modulation of intracellular Ca2+ handling in smooth muscle cells

 

Initial

4 Week after STZ-injection

8 Week after STZ-injection

Body weight (g)

Blood glucose (mM)

Body weight (g)

Blood glucose (mM)

Body weight (g)

Blood glucose (mM)

CON (n = 20)

195.0 ± 25.7

4.2 ± 1.2

423.5 ± 55.8

5.2 ± 0.9

501.0 ± 75.6

5.6 ± 1.5

CON + berberine (n = 20)

186.5 ± 28.1

3.8 ± 2.2

417.9 ± 65.3

4.1 ± 1.2

483.5 ± 72.1

4.5 ± 1.7

Diabetic (n = 20)

190.0 ± 23.4

3.6 ± 1.3

270.3 ± 46.3*

21.9 ± 5.4*

251.0 ± 52.7*

25.91 ± 6.6*

Diabetic + berberine (n = 20)

187.0 ± 25.5

4.1 ± 1.6

327.0 ± 51.2#,*

16.5 ± 4.5#,*

353.0 ± 58.3#,*

14.8 ± 4.3#,*

  1. CON control rats, CON + berberine control rats administrated with berberine (100 mg/kg/day), Diabetic diabetic rats, diabetic + berberine diabetic rats administrated with berberine (100 mg/kg/day). * P < 0.05 vs. CON and # P < 0.05 vs. diabetic rats