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Fig. 8 | Cardiovascular Diabetology

Fig. 8

From: Berberine alleviates the cerebrovascular contractility in streptozotocin-induced diabetic rats through modulation of intracellular Ca2+ handling in smooth muscle cells

Fig. 8

Acute application of berberine directly inhibited the hyperglycemia-induced CaL currents in cerebral VSMCs isolated from normal control rats. Representative traces of CaL channel current at +10 mV in cerebral VSMCs when exposed to 20 mM d-glucose and then subsequent acute application of 10 μM berberine in the presence of 20 mM d-glucose. At last, the cerebral VSMCs were washed with 20 mM d-glucose (a). Summarized data indicated the amplitudes of CaL channel current at +10 mV before and after application of 20 mM d-glucose, 10 μM berberine in the presence of 20 mM d-glucose, and then washing with 20 mM d-glucose (b). Values are mean ± SEM with the number of cells recorded in parentheses. *P < 0.05 vs. control condition and # P < 0.05 vs. high glucose condition

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Cardiovascular Diabetology

ISSN: 1475-2840