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Fig. 4 | Cardiovascular Diabetology

Fig. 4

From: Berberine alleviates the cerebrovascular contractility in streptozotocin-induced diabetic rats through modulation of intracellular Ca2+ handling in smooth muscle cells

Fig. 4

Comparison of CaL peak current density in response to different dose of berberine (50, 100 and 200 mg/kg/day) in cerebral VSMCs isolated from CON, CON + berberine, diabetic, and diabetic + berberine rats. Chronic administration of 50 mg/kg/day berberine had no obvious effects on CaL peak current density in CON and diabetic rats, respectively. However, chronic administration of 100 mg/kg/day berberine did not change the CaL peak current density in CON rats, whereas significantly inhibited the augmented CaL peak current density in diabetic rats, respectively. In addition, chronic administration of 200 mg/kg/day berberine significantly inhibited the CaL peak current density in both CON and diabetic rats, respectively. CON control rats, CON + berberine control rats administrated with berberine, diabetic diabetic rats, diabetic + berberine diabetic rats administrated with berberine. Values are expressed as mean ± SEM and at least n = 10 cells recorded in each group. *P < 0.05 vs. CON rats and # P < 0.05 vs. diabetic rats

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Cardiovascular Diabetology

ISSN: 1475-2840