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Table 1 Baseline characteristics according to diabetic status

From: Hepatic insulin resistance both in prediabetic and diabetic patients determines postprandial lipoprotein metabolism: from the CORDIOPREV study

  Diabetic n = 581 Prediabetic n = 364 Non-diabetic n = 57 p value
Age (years old) 60.78 ± 8.67* 58.41 ± 9.28* 54.68 ± 8.39* 0.005
BMI 31.73 ± 4.54* 30.57 ± 4.26* 28.1 ± 4.54* 0.001
Waist circumference (cm) 107.14 ± 11.69* 103.32 ± 19.88* 96.59 ± 10* 0.001
HbA1c (%) 7.19 ± 1.26* 5.96 ± 0.28* 5.39 ± 0.21* 0.001
AST (mg/dL) 24.72 ± 16.67 26.31 ± 13.16 24 ± 6.37 0.219
ALT (mg/dL) 27.96 ± 23.73 28.58 ± 16.52 27.28 ± 13.88 0.136
Fasting triglycerides (mg/dL) 144.88 ± 72.72* 124.76 ± 62.81 105.75 ± 62,22 0.040
CRP (mg/dL) 2.76 ± 2.13 2.08 ± 1.86 1.61 ± 1.46 0.090
Insulin (mU/L) 12.51 ± 13.50 9.19 ± 6.60 6.92 ± 3.87 0.016
Serum ferritin (ng/mL) 97.45 ± 101.14 108.39 ± 100.77 114.58 ± 99.90 0.001
HOMA-IR 5.49 ± 6.49* 2.13 ± 1.60* 1.56 ± 0.94* 0.001
Fasting glucose (mg/dL) 128.53 ± 44.24* 94.11 ± 10.24 81.18 ± 6.7 0.001
Glucose 2 h OGTT (mg/dL) 257.28 ± 108.35* 125.13 ± 38.35 106.11 ± 21.09 0.001
HIRI 2227.52 ± 2631.69* 1170.36 ± 904.67* 768.57 ± 406.98* 0.001
MIRI 0.025 ± 0.016 0.019 ± 0.021 0.022 ± 0.044 0.100
  1. Values are mean ± SD. One way ANOVA
  2. BMI body mass index, HbA1c glycated hemoglobin, hsCRP high sensitivity C-reactive protein, HOMA-IR homeostatic model assessment insulin resistance, OGTT standard overload glucose tolerance test, HIRI hepatic insulin resistance index, MISI muscle insulin resistance index
  3. * p < 0.05 posthoc Bonferroni analysis according three subgroups