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Table 1 Baseline characteristics according to diabetic status

From: Hepatic insulin resistance both in prediabetic and diabetic patients determines postprandial lipoprotein metabolism: from the CORDIOPREV study

 

Diabetic n = 581

Prediabetic n = 364

Non-diabetic n = 57

p value

Age (years old)

60.78 ± 8.67*

58.41 ± 9.28*

54.68 ± 8.39*

0.005

BMI

31.73 ± 4.54*

30.57 ± 4.26*

28.1 ± 4.54*

0.001

Waist circumference (cm)

107.14 ± 11.69*

103.32 ± 19.88*

96.59 ± 10*

0.001

HbA1c (%)

7.19 ± 1.26*

5.96 ± 0.28*

5.39 ± 0.21*

0.001

AST (mg/dL)

24.72 ± 16.67

26.31 ± 13.16

24 ± 6.37

0.219

ALT (mg/dL)

27.96 ± 23.73

28.58 ± 16.52

27.28 ± 13.88

0.136

Fasting triglycerides (mg/dL)

144.88 ± 72.72*

124.76 ± 62.81

105.75 ± 62,22

0.040

CRP (mg/dL)

2.76 ± 2.13

2.08 ± 1.86

1.61 ± 1.46

0.090

Insulin (mU/L)

12.51 ± 13.50

9.19 ± 6.60

6.92 ± 3.87

0.016

Serum ferritin (ng/mL)

97.45 ± 101.14

108.39 ± 100.77

114.58 ± 99.90

0.001

HOMA-IR

5.49 ± 6.49*

2.13 ± 1.60*

1.56 ± 0.94*

0.001

Fasting glucose (mg/dL)

128.53 ± 44.24*

94.11 ± 10.24

81.18 ± 6.7

0.001

Glucose 2 h OGTT (mg/dL)

257.28 ± 108.35*

125.13 ± 38.35

106.11 ± 21.09

0.001

HIRI

2227.52 ± 2631.69*

1170.36 ± 904.67*

768.57 ± 406.98*

0.001

MIRI

0.025 ± 0.016

0.019 ± 0.021

0.022 ± 0.044

0.100

  1. Values are mean ± SD. One way ANOVA
  2. BMI body mass index, HbA1c glycated hemoglobin, hsCRP high sensitivity C-reactive protein, HOMA-IR homeostatic model assessment insulin resistance, OGTT standard overload glucose tolerance test, HIRI hepatic insulin resistance index, MISI muscle insulin resistance index
  3. * p < 0.05 posthoc Bonferroni analysis according three subgroups