Impaired coronary microcirculation in type 2 diabetic patients is associated with elevated circulating regulatory T cells and reduced number of IL-21R+ T cells

Table 4 Circulating biomarkers in T2D patients in relation to coronary flow reserve in adjusted analyses

Variable	Direction	Coronary flow reserve (n = 37)
Circulating monocytes
Mac_number (CD68)	+	0.23
M0 Mac number (CD14⁺ CD16⁻)	+	0.75
M1 Mac number (C14^dimCD16⁺)	+	0.42
M2 Mac number (CD14⁺CD16⁺)	+	0.32
Mac CD11c_MFI (CD68)	+	0.038
M0 CD14⁺CD16⁻CD11c)	+	0.066
M1 CD14^dimCD16⁺CD11c)	+	0.13
M2 CD14⁺CD16⁺CD11c)	+	0.037
IL-21R on leukocytes in peripheral blood
CD4Tcell_IL21R_number	+	0.23
CD8Tcell_IL21R_number	+	0.002
B cell_IL21R_number	+	0.72
MacIL21R_number	−	0.59
CD4Tcell_IL21R_MFI	+	0.093
CD8Tcells_IL21R_MFI	+	0.41
B cell IL21R (MFI)	+	0.83
CD68 IL21R APC-A mean	−	0.68
TLR4 on leukocytes in peripheral blood
CD4 T cell TLR4 (MFI)	+	0.17
CD8⁺ T cell TLR4 (MFI)	−	0.037
B cell TLR4 (MFI)	−	0.60
Mac TLR4 (MFI)	+	0.75
CD4cell_TLR4_number	+	0.97
CD8Tcell__TLR4_number	−	0.32
BcellsTLR4_number	+	0.22
MacTLR4_number	+	0.36
Regulatory T cells and expression of FoxP3 in T cells
Treg CD25⁺CD127⁻ (number)	−	0.88
Treg CD25⁺CD127⁻FoxP3 (number)	−	0.029
Treg CD25⁺CD127⁻GITR + (number)	−	0.31
TregCD25CD127FoxP3_MFI	−	0.001

Values represent the p values after adjustment for age, sex, body mass index, smoking and diabetes duration. Significant values are highlighted in italics
MFI Mean fluorescence intensity
+ indicates higher values with increasing coronary flow reserve; − indicates lower values with increasing coronary flow reserve

ISSN: 1475-2840