Table 3 Circulating biomarkers in T2D patients vs. controls and in relation to Hba1c as continuous variable in adjusted analyses
Variable | Direction | Controls (n = 16) vs. patients (n = 37) | Hba1c (n = 53) |
|---|---|---|---|
TLR4 on leukocytes in peripheral blood | |||
 CD4 T cell TLR4 (MFI) | − | 0.064 | 0.85 |
 CD8+ T cell TLR4 (MFI) | − | 0.17 | 0.87 |
 B cell TLR4 (MFI) | − | 0.023 | 0.076 |
 Mac TLR4 (MFI) | + | 0.017 | 0.58 |
 CD4cell_TLR4_number | − | <0.0001 | 0.006 |
 CD8Tcell__TLR4_number | − | 0.016 | 0.019 |
 BcellsTLR4_number | − | 0.0005 | 0.075 |
 MacTLR4_number | + | 0.23 | 0.90 |
Regulatory T cells and expression of FoxP3 in T cells | |||
 Treg CD25+CD127− (number) | − | 0.002 | 0.016 |
 Treg CD25+CD127−FoxP3 (number) | − | 0.039 | 0.16 |
 Treg CD25+CD127−GITR+ (number) | − | 0.005 | 0.012 |
 TregCD25CD127FoxP3_MFI | − | 0.29 | 0.076 |