Table 2 Circulating biomarkers in T2D patients vs. controls and in relation to Hba1c as continuous variable in adjusted analyses
Variable | Direction | Controls (n = 16) vs. patients (n = 37) | Hba1c (n = 53) |
|---|---|---|---|
Circulating lymphocytes | |||
 CD4Tcell_number | − | 0.003 | 0.09 |
 CD8tcell_number | + | 0.45 | 0.40 |
 B cells (number) CD19 #Events | − | 0.37 | 0.36 |
 Th17CCR6IL21R_number | − | 0.004 | 0.024 |
 TfH CXCR5+CCR6+ICOS+ (number) | + | 0.031 | 0.76 |
Circulating monocytes | |||
 Mac_number (CD68) | − | 0.45 | 0.49 |
 M0 Mac number (CD14+CD16−) | + | 0.16 | 0.74 |
 M1 Mac number (C14dimCD16+) | − | 0.006 | 0.72 |
 M2 Mac number (CD14+CD16+) | − | 0.75 | 0.66 |
 Mac CD11c_MFI (CD68) | − | 0.93 | 0.24 |
 M0 CD14+CD16−CD11c) | − | 0.93 | 0.20 |
 M1 CD14dimCD16+CD11c) | + | 0.031 | 0.88 |
 M2 CD14+CD16+CD11c) | − | 0.65 | 0.92 |
IL-21R on leukocytes in peripheral blood | |||
 CD4Tcell_IL21R_number | − | <0.0001 | 0.003 |
 CD8Tcell_IL21R_number | − | 0.0009 | 0.048 |
 B cell_IL21R_number | − | 0.14 | 0.18 |
 MacIL21R_number | − | 0.003 | 0.40 |
 CD4Tcell_IL21R_MFI | − | <0.0001 | 0.0001 |
 CD8Tcells_IL21R_MFI | − | 0.004 | 0.006 |
 B cell IL21R (MFI) | − | 0.023 | 0.076 |
 CD68 IL21R APC-A Mean | − | 0.38 | 0.62 |