Fig. 6
From: Nicorandil attenuates carotid intimal hyperplasia after balloon catheter injury in diabetic rats
Effect of εPKC on intimal hyperplasia in balloon-injured carotid arteries. a Representative western blots for εPKC translocation in injured carotid artery treated with or without nicorandil or 5-HD. b Quantitative analysis of εPKC translocation. εPKC translocation from the cell soluble (S) to the cell particulate fraction (TS) was observed after balloon injury. This translocation was blocked by nicorandil. The effect of nicorandil was reversed by 5-HD. c Representative western blots for εPKC protein in the injured carotid artery with or without εPKC siRNA. d Quantitative analysis of εPKC protein. εPKC expression in εPKC siRNA delivered group was reduced to 30.41 ± 5.17 % of that in the scramble siRNA delivered group e: Representative cross-section of carotid artery stained with Elastica van Gieson. f Quantitative analysis of of intima/media ratio. g Quantitative analysis of lumen area in DM-injury + scramble siRNA group and DM-injury + εPKC siRNA group. Knockdown of εPKC reduced the intima/media ratio and increased lumen area. Bars represent mean ± SE. **p < 0.01