Table 2 Hazard ratio and 95 % confidence interval of type 2 diabetes according to measures of oxidative stress and inflammation: CARDIA year 15–25 (2000–2001 to 2010–11)

F2-isoprostanes

 N cases/N

36/591

45/576

56/579

85/593

 Model 1

1.00

1.12 (0.72–1.75)

1.25 (0.81–1.93)

1.83 (1.18–2.83)

 Model 2

1.00

1.09 (0.70–1.70)

1.28 (0.83–1.98)

1.61 (1.03–2.52)

 Model 3

1.00

1.10 (0.71–1.72)

1.14 (0.73–1.76)

1.22 (0.77–1.93)

 Model 4

1.00

1.19 (0.76–1.86)

1.17 (0.75–1.81)

1.43 (0.90–2.26)

Oxidized LDL

 N cases/N

31/580

43/588

70/598

78/573

 Model 1

1.00

1.25 (0.79–1.99)

2.06 (1.34–3.17)

1.97 (1.27–3.05)

 Model 2

1.00

1.29 (0.81–2.05)

2.16 (1.41–3.31)

2.09 (1.37–3.18)

 Model 3

1.00

1.03 (0.65–1.65)

1.76 (1.14–2.71)

1.46 (0.94–2.28)

 Model 4

1.00

1.06 (0.66–1.70)

1.62 (1.05–2.51)

1.31 (0.83–2.04)

Inflammation

 C-reactive protein

  N cases/N

18/582

44/602

51/587

109/568

  Model 1

1.00

1.88 (1.08–3.28)

1.97 (1.14–3.39)

3.98 (2.36–6.71)

  Model 2

1.00

1.83 (1.05–3.18)

1.67 (0.96–2.90)

2.95 (1.73–5.04)

  Model 3

1.00

1.63 (0.93–2.84)

1.42 (0.82–2.48)

2.06 (1.17–3.61)

  Model 4

1.00

1.64 (0.94–2.87)

1.41 (0.81–2.46)

2.21 (1.26–3.88)