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Fig. 1 | Cardiovascular Diabetology

Fig. 1

From: Oxidative stress, inflammation, endothelial dysfunction and incidence of type 2 diabetes

Fig. 1

Results from the Improvement in Prediction Probability analysis adding E-selectin and ICAM-1 to a base risk score for T2D: The base risk score was ranked into quartiles (Q1–Q4). For each BP quartile, observed T2D incidence was plotted (middle bar in bold) as a reference point without reclassification. For each participant k, reclassification probability < 0 is labeled “Down”. Reclassification probability ≥0 is labeled “Up”. Participants reclassified “down” and “up” are plotted to the left and right of overall base risk within each BP quartile. The numbers on the X axis of the graph represent the N reclassified down or up and the overall N of the quartile (N “down” + N “up” = N “base”). The numbers (in italics) above each bar represent the estimated probability of incident T2D in participants reclassified down and up. When the probability of incident T2D for reclassification “up” is greater than the probability of incident T2D for reclassification “down”, there is improvement in prediction probability. A formal statistical test used Poisson regression of incident T2D dependent variable) on AP–BP, adjusting for BP. The Relative Risk for the midpoint of those reclassified “up” (75th percentile of AP–BP) vs the midpoint of reclassification “down” (75th percentile of AP–BP) was 1.09, 95 % Confidence interval (1.06–1.13), P < 0.0001

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