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Table 4 Sex-stratified risk for incident diabetes by quartile of 2 h plasma insulin among participants with normal blood pressure and prehypertension

From: Metabolic markers associated with insulin resistance predict type 2 diabetes in Koreans with normal blood pressure or prehypertension

 

Number at risk

Diabetes cases

Unadjusted

Model 1

Model 2

HR (95 % CI)

P for trend

HR (95 % CI)

P for trend

HR (95 % CI)

P for trend

Normal BP

 Men

  Quartile 1

446

43

1 (reference)

<0.001

1 (reference)

<0.001

1 (reference)

<0.001

  Quartile 2

443

48

1.06 (0.70–1.60)

1.07 (0.71–1.61)

1.09 (0.72–1.64)

  Quartile 3

440

57

1.31 (0.88–1.94)

1.34 (0.90–1.99)

1.27 (0.85–1.90)

  Quartile 4

443

79

1.90 (1.31–2.76)*

1.94 (1.34–2.82)*

1.50 (1.02–2.21)*

 Women

  Quartile 1

541

36

1 (reference)

<0.001

1 (reference)

<0.001

1 (reference)

<0.001

  Quartile 2

542

41

1.13 (0.72–1.76)

1.14 (0.73–1.79)

1.16 (0.74–1.82)

  Quartile 3

543

56

1.53 (1.01–2.34)*

1.60 (1.05–2.44)*

1.60 (1.05–2.45)*

  Quartile 4

538

79

2.15 (1.45–3.18)**

2.19 (1.48–3.25)**

2.02 (1.35–3.02)**

Prehypertension

 Men

  Quartile 1

241

35

1 (reference)

<0.001

1 (reference)

<0.001

1 (reference)

<0.001

  Quartile 2

234

34

0.91 (0.57–1.46)

0.89 (0.56–1.43)

0.85 (0.53–1.37)

  Quartile 3

239

39

1.14 (0.72–1.80)

1.14 (0.72–1.80)

1.10 (0.69–1.74)

  Quartile 4

235

60

1.70 (1.12–2.58)*

1.78 (1.17–2.71)*

1.42 (0.92–2.18)

 Women

  Quartile 1

205

24

1 (reference)

<0.001

1 (reference)

<0.001

1 (reference)

<0.001

  Quartile 2

204

28

1.16 (0.67–2.00)

1.15 (0.67–1.99)

1.18 (0.68–2.05)

  Quartile 3

207

33

1.26 (0.75–2.13)

1.25 (0.74–2.12)

1.38 (0.81–2.34)

  Quartile 4

201

41

1.67 (1.01–2.77)*

1.70 (1.02–2.82)*

1.63 (0.97–2.73)

  1. Model 1: adjusted for age
  2. Model 2: adjusted for the variables in model 1 and fasting plasma glucose, body mass index, family history of diabetes (yes or no), education (less than high school, high school or equivalent, or college or above), alcohol use (current or non-current), and smoking status (current or non-current)
  3. * P < 0.05, ** P < 0.001