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Table 3 Platelet function profiles according to rs13431554 genotype in study population

From: Association between insulin receptor substrate-1 polymorphisms and high platelet reactivity with clopidogrel therapy in coronary artery disease patients with type 2 diabetes mellitus

 

DM patients

p

Non-DM patients

p

AA

AG + GG

AA

AG + GG

Platelet aggregation (%)

 ADP

52.0 ± 17.9

56.8 ± 16.2

<0.01

48.5 ± 17.4

51.1 ± 18.6

0.35

 AA

25.2 ± 17.8

28.9 ± 18.6

<0.01

22.3 ± 14.9

24.8 ± 16.4

0.29

Platelet activation (%)

 PAC-1

36.2 ± 13.8

40.8 ± 12.4

0.01

34.8 ± 11.8

36.5 ± 13.1

0.37

 P-selectin

38.7 ± 19.9

43.7 ± 15.9

0.03

36.4 ± 17.0

39.0 ± 16.2

0.31

  1. Data are expressed as mean ± SD of percentages of platelet aggregation or percentages of positive platelets
  2. ADP adenosine diphosphate; AA arachidonic acid
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Cardiovascular Diabetology

ISSN: 1475-2840