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Table 4 Multivariable Cox regression models showing the association between sTNFR1 and sTNFR2, with mortality in all individuals and in those without kidney disease

From: Association of soluble tumor necrosis factor receptors 1 and 2 with nephropathy, cardiovascular events, and total mortality in type 2 diabetes

Biomarker

Model

Hazard ratio

95 % confidence intervals

p value

sTNFR1 all

A

1.47

(1.19–1.83)

<0.001

B

1.50

(1.21–1.86)

<0.001

C

1.40

(1.11–1.76)

0.004

D

1.49

(1.19–1.86)

<0.001

E

1.45

(1.14–1.85)

0.003

Without kidney disease

A

1.65

(1.32–2.05)

<0.001

B

1.67

(1.34–2.09)

<0.001

C

1.58

(1.25–2.00)

<0.001

D

1.71

(1.35–2.17)

<0.001

E

1.70

(1.28–2.25)

<0.001

sTNFR2

A

1.50

(1.18–1.91)

0.001

B

1.52

(1.19–1.94)

0.001

C

1.41

(1.08–1.83)

0.010

D

1.51

(1.18–1.93)

0.001

E

1.58

(1.20–2.09)

0.001

Without kidney disease

A

1.65

(1.28–2.13)

<0.001

B

1.69

(1.31–2.18)

<0.001

C

1.54

(1.16–2.05)

0.003

D

1.66

(1.28–2.15)

<0.001

E

1.95

(1.40–2.70)

<0.001

  1. Model A: adjusted for age, and sex; Model B: adjusted for age, sex, eGFR and ACR; Model C: adjusted for age, sex, CRP IL-6; Model D: adjusted for age, sex, HbA1c, and diabetes treatment (diet, oral antidiabetics or insulin); E (secondary analysis): established cardiovascular risk factors (smoking, LDL-cholesterol, HDL-cholesterol, systolic blood pressure), cardiovascular medication, antihypertensive medication (ACE-inhibitors/ARBs, calcium channel blockers, beta blockers and diuretics), and lipid lowering treatment (statins), to model B