Fig. 8
From: Interleukin-1β mediates high glucose induced phenotypic transition in human aortic endothelial cells
Anti-IL-1β antibodies inhibited high glucose-induced phenotypic transition of HAECs, as assessed by transmission electron microscopy. Transmission electron microscopy depicts the change in cellular ultrastructure following HG (30 mM) exposure (left magnification ×10,000,vs right magnification ×40,000 in the same group). a It can be seen that normal HAECs present with few microfilaments and a rough endoplasmic reticulum. b After exposure to HG, microfilamentation and a swollen rough endoplasmic reticulum appeared in the cytoplasm. c These changes were attenuated by treatment with anti-IL-1β antibodies. a normal glucose (5.5 mM) group, b high glucose (30 mM) group for 48 h; c treatment with a high glucose concentration (30 mM) + anti-IL-1β antibodies (1000 ng/ml) treatment for 48 h