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Fig. 3 | Cardiovascular Diabetology

Fig. 3

From: Low circulating pentraxin 3 levels in pregnancy is associated with gestational diabetes and increased apoB/apoA ratio: a 5-year follow-up study

Fig. 3

Model integrating the cardio-metabolic effects of low PTX3 in GDM. a In the presence of obesity and low grade inflammation, 1 low PTX3 may enhance insulin resistance through diminished effects on glucose transport proteins. 2 Decreased PTX3 may enhance complement mediated inflammation and promote recruitment of leukocytes to inflamed endothelium. 3 Low HDL-C may suppress PTX3 expression and release from endothelial cells (EC). b Although these effects may not result in manifest CVD disease they may associate with an enhanced risk profile post partum and possible clinical disease in the long run. In the presence of advanced atherogenesis and incident CVD, a compensatory increase in PTX3 will be associated with adverse outcome

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Cardiovascular Diabetology

ISSN: 1475-2840