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Table 2 Top differentially expressed genes in CD34+cells induced by hyperglycemia–hypoxia for 3 h versus hyperglycemia

From: Metformin improves the angiogenic potential of human CD34+ cells co-incident with downregulating CXCL10 and TIMP1 gene expression and increasing VEGFA under hyperglycemia and hypoxia within a therapeutic window for myocardial infarction

Gene name

Gene symbol

p value

FC

Non-SMC condensin I complex, subunit H

NCAPH

1.46E−09

2.24

Polo-like kinase 1

PLK1

1.54E−09

4.71

Cyclin A2

CCNA2

1.94E−09

2.57

Serine/arginine-rich splicing factor 4

SRSF4

1.15E−08

−1.73

Protein regulator of cytokinesis 1

PRC1

1.17E−08

2.17

TIMP metallopeptidase inhibitor 3

TIMP3

1.24E−08

2.14

Lysine (K)-specific demethylase 5D

KDM5D

2.59E−08

1.86

TPX2, microtubule-associated, homolog (Xenopus laevis)

TPX2

6.63E−08

2.64

Cell division cycle 20 homolog (S. cerevisiae)

CDC20

8.42E−08

3.08

Olfactory receptor, family 2, subfamily L, member 13

OR2L13

9.20E−08

−1.93

Prohibitin

PHB

9.25E−08

1.99

ZW10 interactor

ZWINT

9.82E−08

1.93

X-ray repair complementing defective repair in Chinese hamster cells 2

XRCC2

1.44E−07

1.61

Brain expressed, X-linked 4

BEX4

1.47E−07

−1.76

Protein kinase, membrane associated tyrosine/threonine 1

PKMYT1

1.61E−07

2.14

Golgin A8 family, member B

GOLGA8B

1.62E−07

−1.64

Holliday junction recognition protein

HJURP

1.67E−07

2.55

S100 calcium binding protein A8

S100A8

2.10E−07

−5.24

TIMP metallopeptidase inhibitor 1

TIMP1

6.34E−06

2.36

Chemokine (C–X–C motif) ligand 10

CXCL10

2.04E−02

1.89

  1. The gene list was created by importing Affymetrix .CEL files to Partek Genomic Suite version 6.6. The data were RMA normalized. Differentially expressed gene list was generated using one-way ANOVA, Benjamini and FDR-unadjusted p value <0.05 with a fold change cutoff of 1.5 was applied