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Fig. 3 | Cardiovascular Diabetology

Fig. 3

From: Metformin improves the angiogenic potential of human CD34+ cells co-incident with downregulating CXCL10 and TIMP1 gene expression and increasing VEGFA under hyperglycemia and hypoxia within a therapeutic window for myocardial infarction

Fig. 3

Summary of the effect of metformin on CD34+ cells incubated with hyperglycemia–hypoxia. CD34+ cells were treated with hyperglycemia–hypoxia versus euglycemia (a), and hyperglycemia–hypoxia with metformin versus metformin untreated-condition (b). Green shading indicates downregulation, orange shading indicate upregulation and gray shading indicate unchanged gene expression. In vitro tube formation (angiogenesis), green shading indicates inhibition, whereas orange shading indicates activation

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