Fig. 6
Linear plots of intima-media thickness (IMT) as well as the change in IMT between EDIC years 1–6 vs. markers for skin fluorescence (LW-1, SIF), as indicated. Preliminary Spearman correlation analysis showed that LW-1 and SIF (but not CLF) significantly (P < 0.05) correlated with IMT at EDIC year 6, but not at year 1. Further linear regression analysis showed that IMT (for both years) significantly correlated with age (P < 0.0001), HbA1c (P = 0.013) and borderline nonsignificantly with diabetes duration (P = 0.068). Thus, all variables in these graphs have been adjusted for age, diabetes duration and HbA1c (both DCCT and EDIC). For all graphs, the regression line and 95 % CI prediction of data points are shown: (left) IMT = 5.64 + 0.001 (LW-1), n = 127; (middle) IMT = 5.68 + 0.028 (SIF), n = 121; (right) change in IMT between EDIC year 1 and 6, ∆IMT = 0.001(LW-1)–0.339, n = 121. All values for IMT and ∆IMT have been multiplied by 10. For each graph, the correlation (r) and significance (P) are inserted. Symbols used: see Fig. 1