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Fig. 1 | Cardiovascular Diabetology

Fig. 1

From: Skin collagen fluorophore LW-1 versus skin fluorescence as markers for the long-term progression of subclinical macrovascular disease in type 1 diabetes

Fig. 1

Unadjusted LW-1 vs. age in skin collagen digests of DCCT patients. For all graphs, regression lines and 95 % CI prediction for nondiabetic controls are shown. a Unadjusted LW-1 expressed as a percentage of total fluorescence at ex/em 348/463 nm in skin collagen digests vs. age. Percent LW-1 was determined by manually collecting the LW-1 peak by HPLC and comparing its fluorescence yield with that of the digest itself at wavelengths same as described in the “Methods” section. b and c Unadjusted LW-1 levels vs. age at DCCT closeout in the primary and secondary cohorts. Regression lines: a y = 3.4 + 0.172x, r = 0.48, P = 0.002, n = 39. b and c y = 1.8 + 6.6x, r = 0.64, P < 0.0001, n = 42. Treatment (cohort) circle, conventional (primary); triangle, conventional (secondary); filled circle, intensive (primary); filled triangle, intensive (secondary)

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Cardiovascular Diabetology

ISSN: 1475-2840