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Fig. 8 | Cardiovascular Diabetology

Fig. 8

From: High glucose-induced hyperosmolarity contributes to COX-2 expression and angiogenesis: implications for diabetic retinopathy

Fig. 8

The involvement of AQP1 in COX-2 expression in the Ins2Akita and C57BL/6 mice. a Western analysis of COX-2 and AQP1 expression in retinas from from D2.B6-Ins2 Akita and sex- and age-matched (1 year-old) C57BL/6 non-diabetic control mice, after the intravitreal injection of saline (sham), or siRNA against scrambled sequence (siRNA-scr) or siRNA against AQP1 (siRNA-AQP1), with β-actin serving as a loading control. b n = 2 eyes per animal, with each experimental group consisting of n = 7 mice. The bar graph represents the means ± S.D. from three separate experiments. **, P < 0.01 vs C57BL/6 control mice °°, P < 0.01 vs sham and siRNA-scr. Glyco AQP1 represents the glycosylated form of AQP1 able to insert itself in the plasma membrane

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Cardiovascular Diabetology

ISSN: 1475-2840