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Table 3 Demographic and clinical characteristics stratified by WC according ATPIII and IISHMS

From: LEADER 5: prevalence and cardiometabolic impact of obesity in cardiovascular high-risk patients with type 2 diabetes mellitus: baseline global data from the LEADER trial

 

All

WC-ATPIII

WC-IISHMS

Off target

On target

Off target

On target

(n = 9263)

(n = 7330)

(n = 1933)

(n = 8678)

(n = 585)

Age (years)

64.3 ± 7.2

64.3 ± 7.2

64.3 ± 7.4

64.3 ± 7.2

64.2 ± 7.4

Gender

 Female

3305

3050 (92.3 %)

255 (7.7 %)

3232 (97.8 %)

73 (2.2 %)

 Male

5958

4280 (71.8 %)

1678 (28.2 %)

5446 (91.4 %)

512 (8.6 %)

Age group

 50–59 years

2305

1822 (79.0 %)

483 (21.0 %)

2165 (93.9 %)

140 (6.1 %)

 60–69 years

4806

3835 (79.8 %)

971 (20.2 %)

4501 (93.7 %)

305 (6.3 %)

 70–79 years

1954

1518 (77.7 %)

436 (22.3 %)

1829 (93.6 %)

125 (6.4 %)

 80–89 years

194

153 (78.9 %)

41 (21.1 %)

180 (92.8 %)

14 (7.2 %)

 90–99 years

4

2 (50.0 %)

2 (50.0 %)

3 (75.0 %)

1 (25.0 %)

Region

 Europe

3489

2873 (82.3 %)

616 (17.7 %)

3322 (95.2 %)

167 (4.8 %)

 Other areas

2600

2053 (79.0 %)

547 (21.0 %)

2449 (94.2 %)

151 (5.8 %)

 United States

2465

2092 (84.9 %)

373 (15.1 %)

2345 (95.1 %)

120 (4.9 %)

 Asia

709

312 (44.0 %)

397 (56.0 %)

562 (79.3 %)

147 (20.7 %)

Race

 Asian

919

420 (45.7 %)

499 (54.3 %)

741 (80.6 %)

178 (19.4 %)

 Black

771

632 (82.0 %)

139 (18.0 %)

725 (94.0 %)

46 (6.0 %)

 Other

403

298 (73.9 %)

105 (26.1 %)

374 (92.8 %)

29 (7.2 %)

 Caucasian

7170

5980 (83.4 %)

1190 (16.6 %)

6838 (95.4 %)

332 (4.6 %)

Ethnicity

 Hispanic or latino

1127

840 (74.5 %)

287 (25.5 %)

1070 (94.9 %)

57 (5.1 %)

 Not hispanic or latino

8136

6490 (79.8 %)

1646 (20.2 %)

7608 (93.5 %)

528 (6.5 %)

eGFR category (mL/min/1.73 m2)

 Normal (≥90)

3415

2654 (77.7 %)

761 (22.3 %)

3183 (93.2 %)

232 (6.8 %)

 Mild (60–90)

3831

3068 (80.1 %)

763 (19.9 %)

3590 (93.7 %)

241 (6.3 %)

 Moderate (30–60)

1842

1475 (80.1 %)

367 (19.9 %)

1742 (94.6 %)

100 (5.4 %)

 Severe (<30)

173

132 (76.3 %)

41 (23.7 %)

161 (93.1 %)

12 (6.9 %)

Smoker

 Current smoker

1117

833 (74.6 %)

284 (25.4 %)

1023 (91.6 %)

94 (8.4 %)

 Never smoked

3852

3057 (79.4 %)

795 (20.6 %)

3611 (93.7 %)

241 (6.3 %)

 Previous smoker

4294

3440 (80.1 %)

854 (19.9 %)

4044 (94.2 %)

250 (5.8 %)

CVD stratum

 No prior CVD group

1736

1398 (80.5 %)

338 (19.5 %)

1636 (94.2 %)

100 (5.8 %)

 Prior CVD group

7527

5932 (78.8 %)

1595 (21.2 %)

7042 (93.6 %)

485 (6.4 %)

Diabetes duration (years)

12.7 ± 8.0

12.5 ± 8.0

13.5 ± 8.3

12.6 ± 8.0

13.9 ± 8.7

HbA1c (%)

8.7 ± 1.5

8.7 ± 1.5

8.7 ± 1.6

8.7 ± 1.5

8.7 ± 1.7

HbA1c (mmol/mol)

(71.6 ± 16.4)

(71.6 ± 16.4)

(71.6 ± 17.5)

(71.6 ± 16.4)

(71.6 ± 18.6)

Blood lipids

 LDL-C (mmol/L)

2.3 ± 0.9

2.3 ± 0.9

2.3 ± 0.9

2.3 ± 0.9

2.2 ± 0.9

 HDL-C (mmol/L)

1.2 ± 0.3

1.2 ± 0.3

1.2 ± 0.3

1.2 ± 0.3

1.3 ± 0.4

 Triglycerides (mmol/L)

2.1 ± 1.6

2.1 ± 1.6

1.7 ± 1.5

2.1 ± 1.6

1.6 ± 1.6

Blood pressure

 Systolic blood pressure (mmHg)

138 ± 19

138 ± 19

136 ± 19

138 ± 19

135 ± 18

 Diastolic blood pressure (mmHg)

78 ± 11

78 ± 11

77 ± 10

78 ± 11

76 ± 10

  1. Values are expressed as mean ± SD or frequency (percent of row). ATPIII Adult Treatment Panel III criteria; CVD cardiovascular disease; eGFR estimated glomerular filtration rate; HbA1c glycated haemoglobin; HDL-C high-density lipoprotein cholesterol; IISHMS International Joint Interim Statement for the Harmonization of the Metabolic Syndrome criteria; LDL-C low-density lipoprotein cholesterol; SD standard deviation; WC waist circumference