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Table 1 Demographic and clinical characteristics stratified by CVD

From: LEADER 5: prevalence and cardiometabolic impact of obesity in cardiovascular high-risk patients with type 2 diabetes mellitus: baseline global data from the LEADER trial

 

All

No prior CVD group

Prior CVD group

(n = 9340)

(n = 1748)

(n = 7592)

Age (years)

64.3 ± 7.2

65.8 ± 5.2

63.9 ± 7.6

Gender

 Female

3337 (35.7 %)

793 (45.4 %)

2544 (33.5 %)

 Male

6003 (64.3 %)

955 (54.6 %)

5048 (66.5 %)

Age group

 50–59 years

2321 (24.9 %)

26 (1.5 %)

2295 (30.2 %)

 60–69 years

4839 (51.8 %)

1337 (76.5 %)

3502 (46.1 %)

 70–79 years

1977 (21.2 %)

359 (20.5 %)

1618 (21.3 %)

 80–89 years

199 (2.1 %)

26 (1.5 %)

173 (2.3 %)

 90–99 years

4 (0.0 %)

0 (0.0 %)

4 (0.1 %)

BMI (kg/m2)

 <25.0

865 (9.3 %)

172 (9.8 %)

693 (9.1 %)

 25 to <30

2671 (28.6 %)

520 (29.7 %)

2151 (28.3 %)

 30 to <35

2987 (32.0 %)

535 (30.6 %)

2452 (32.3 %)

 35 to <40

1715 (18.4 %)

310 (17.7 %)

1405 (18.5 %)

 ≥40.0

1092 (11.7 %)

210 (12.0 %)

882 (11.6 %)

WC ATIII target

 Yes

1933 (20.7 %)

338 (19.3 %)

1595 (21.0 %)

 No

7330 (78.5 %)

1398 (80.0 %)

5932 (78.1 %)

 Missing values

77 (0.8 %)

12 (0.7 %)

65 (0.9 %)

WC-IISHMS target

 Yes

585 (6.3 %)

100 (5.7 %)

485 (6.4 %)

 No

8678 (92.9 %)

1636 (93.6 %)

7042 (92.8 %)

 Missing values

77 (0.8)

12 (0.7)

65 (0.9 %)

HbA1c (%)

8.7 (1.6)

8.8 (1.5)

8.7 (1.6)

HbA1c (mmol/mol)

71.6 (17.5)

72.7 (16.4)

71.6 (17.5)

Blood lipids

 LDL-C (mmol/L)

2.3 (0.9)

2.5 (0.9)

2.3 (0.9)

 HDL-C (mmol/L)

1.2 (0.3)

1.2 (0.3)

1.2 (0.3)

 Triglycerides (mmol/L)

2.1 (1.6)

2.0 (1.5)

2.1 (1.6)

No OAD use at baseline

4409 (47.2 %)

744 (42.6 %)

3665 (48.3 %)

Pre-treatment

 None/diet

504 (5.4)

99 (5.7)

405 (5.3)

 Insulines only

665 (7.1)

69 (3.9)

596 (7.9)

 OADs only

4931 (52.8)

1004 (57.4)

3927 (51.7)

 Ins + OADs

3240 (34.7)

576 (33.0)

2644 (35.1)

Use of antihypertensive medication

 Yes

8550 (91.5 %)

1473 (84.3 %)

7077 (93.2 %)

 No

790 (8.5 %)

275 (15.7 %)

515 (6.8 %)

  1. Values are expressed as mean ± SD or frequency (percent of row). ATPIII Adult treatment panel III criteria; CVD cardiovascular disease; eGFR estimated glomerular filtration rate; HbA1c glycated haemoglobin; HDL-C high-density lipoprotein cholesterol; IISHMS International Joint Interim Statement for the Harmonization of the Metabolic Syndrome criteria; LDL-C low-density lipoprotein cholesterol; SD standard deviation; WC waist circumference