Skip to main content

Table 4 Aortic uptake of 18F-FMCH and 18F-FDG in ex vivo autoradiography

From: Type 2 diabetes enhances arterial uptake of choline in atherosclerotic mice: an imaging study with positron emission tomography tracer 18F-fluoromethylcholine

 

18F-FMCH

18F-FDG

LDLR−/−ApoB100/100

IGF-II/LDLR−/−ApoB100/100

C57BL/6N

LDLR−/−ApoB100/100

IGF-II/LDLR−/−ApoB100/100

Adventitia

140 ± 9.1

160 ± 12

100 ± 8.4a

210 ± 39

130 ± 12

Wall

76 ± 5.8

89 ± 6.8

69 ± 7.5

160 ± 18

140 ± 12

Plaque

190 ± 11

240 ± 20a

NA

320 ± 30

290 ± 20

Plaque-to-wall ratio

2.5 ± 0.10

2.6 ± 0.085

NA

2.1 ±0.16

2.1 ± 0.16

Plaque vs. wall p value

<0.001

<0.001

NA

0.0023

<0.001

Plaque vs. adventitia p value

0.018

0.022

NA

0.061

<0.001

  1. Uptake of the tracers in different parts of vascular tissue are measured in non-diabetic (LDLR−/−ApoB100/100) and diabetic (IGF-II/LDLR−/−ApoB100/100) atherosclerotic mice and in healthy (C57BL/6N) controls. The results are expressed as count densities (photo-stimulated luminescence per mm2, mean ± SEM).
  2. NA not applicable
  3. aa significant difference as compared with LDLR−/−ApoB100/100 mice