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Table 2 Quantitative results of histology in non-diabetic (LDLR−/−ApoB100/100) and diabetic (IGF-II/LDLR−/−ApoB100/100) atherosclerotic mice

From: Type 2 diabetes enhances arterial uptake of choline in atherosclerotic mice: an imaging study with positron emission tomography tracer 18F-fluoromethylcholine

 

LDLR−/−ApoB100/100 (n = 8)

IGF-II/LDLR−/−ApoB100/100 (n = 9)

Intima-to-media ratio (plaque size)

2.7 ± 0.88

1.8 ± 0.51

Mac-3 positive area (%)

15 ± 2.3

17 ± 0.98

iNOS positive area (%)

14 ± 1.3

14 ± 1.7

MRC-1 positive area (%)

30 ± 1.3

32 ± 1.2

CD36 positive area (%)

24 ± 1.6

28 ± 0.66

  1. In addition to plaque size (intima-to-media ratio), areal percentages of macrophages (Mac-3), M1 polarized macrophages (iNOS), M2 polarized macrophages (MRC-1) and scavenger receptor (CD36) in atherosclerotic lesions in the aortic root are shown. The data are expressed as mean ± SEM. No statistically significant differences were observed between the mouse strains