Evaluation of pleiotropic effects among common genetic loci identified for cardio-metabolic traits in a Korean population

Table 4 Pleiotropic association between lipid risk scores and cardio-metabolic traits

Lipid RS	SBP		DBP		FPG		BMI		WHR
Lipid RS	Effect size	P value	Effect size	P value	Effect size	P value	Effect size	P value	Effect size	P value
LDL_RS	−0.24 ± 0.07	2.87 × 10⁻⁴	−0.12 ± 0.04	3.82 × 10⁻³	−0.17 ± 0.04	2.43 × 10⁻⁶	−0.02 ± 0.01	0.085	−0.0006 ± 0.0002	8.55 × 10⁻³
HDL_RS	−0.32 ± 0.07	9.05 × 10⁻⁶	−0.15 ± 0.05	1.54 × 10⁻³	−0.18 ± 0.04	7.17 × 10⁻⁶	−0.02 ± 0.01	0.165	−0.0004 ± 0.0002	0.113
TG_RS	−0.20 ± 0.07	5.57 × 10⁻³	−0.07 ± 0.05	0.103	−0.19 ± 0.04	1.55 × 10⁻⁶	−0.02 ± 0.01	0.160	−0.0007 ± 0.0002	2.07 × 10⁻³
TC_RS	0.08 ± 0.10	0.457	0.03 ± 0.07	0.623	0.26 ± 0.06	3.27 × 10⁻⁶	0.04 ± 0.02	6.21 × 10⁻³	0.0010 ± 0.0003	2.52 × 10⁻³
wLDL_RS	−0.04 ± 0.02	3.03 × 10⁻²	−0.04 ± 0.01	4.95 × 10⁻³	−0.06 ± 0.01	1.59 × 10⁻⁷	−0.02 ± 0.00	5.77 × 10⁻⁹	−0.0003 ± 0.0001	2.69 × 10⁻⁵
wHDL_RS	0.18 ± 0.05	4.42 × 10⁻⁴	0.17 ± 0.03	1.45 × 10⁻⁷	0.02 ± 0.03	0.396	0.07 ± 0.01	1.44 × 10⁻¹⁸	0.0017 ± 0.0002	8.11 × 10⁻²⁵
wTG_RS	0.02 ± 0.01	0.070	0.01 ± 0.01	0.161	−0.01 ± 0.005	0.237	−0.003 ± 0.001	1.73 × 10⁻²	−0.00001 ± 0.00003	0.798
wTC_RS	−0.03 ± 0.02	0.183	−0.02 ± 0.01	0.125	−0.08 ± 0.01	2.32 × 10⁻¹⁰	−0.02 ± 0.004	1.55 × 10⁻⁶	−0.0002 ± 0.0001	8.87 × 10⁻³

Lipid RS lipid risk score, LDL_RS unweighted LDL risk score, HDL_RS unweighted HDL risk score, TG_RS unweighted TG risk score, TC_RS unweighted TC risk score, wLDL_RS weighted LDL risk score, wHDL_RS weighted HDL risk score, wTG_RS weighted TG risk score, wTC_RS weighted TC risk score, SBP systolic blood pressure, DBP diastolic blood pressure, FPG fasting plasma glucose, BMI body mass index, WHR waist-hip ratio
Effect size are shown as beta ± standard error. All of analyses were adjusted by age, sex and lipids

ISSN: 1475-2840