Evaluation of pleiotropic effects among common genetic loci identified for cardio-metabolic traits in a Korean population

Table 2 Pleiotropic effects of three SNPs located in the 12q24.12 region

Traits	n	rs671, ALDH2		rs11066015, ACAD10		rs3782886, BRAP
Traits	n	Effect size (beta ± s.e.)	P	Effect size (beta ± s.e.)	P	Effect size (beta ± s.e.)	P
Lipids
TC	13,378	−0.03 ± 0.59	0.9547	−0.03 ± 0.59	0.9633	−0.26 ± 0.58	0.6502
TG	13,378	−7.60 ± 1.72	9.47 × 10⁻⁶	−7.28 ± 1.71	2.11 × 10⁻⁵	−6.93 ± 1.68	3.53 × 10⁻⁵
LDL	13,378	2.55 ± 0.53	1.53 × 10⁻⁶	2.54 ± 0.53	1.50 × 10⁻⁶	2.13 ± 0.52	3.80 × 10⁻⁵
HDL	13,378	−1.33 ± 0.18	1.20 × 10⁻¹³	−1.33 ± 0.18	7.61 × 10⁻¹⁴	−1.33 ± 0.17	2.97 × 10⁻¹⁴
Blood pressure
SBP	10,310	−1.49 ± 0.32	2.72 × 10⁻⁶	−1.53 ± 0.32	1.33 × 10⁻⁶	−1.34 ± 0.31	1.50 × 10⁻⁵
DBP	10,310	−0.80 ± 0.21	1.09 × 10⁻⁴	−0.82 ± 0.21	7.12 × 10⁻⁵	−0.78 ± 0.20	1.02 × 10⁻⁴
Glycemic traits
FPG	13,378	−0.96 ± 0.17	2.00 × 10⁻⁸	−0.92 ± 0.17	5.93 × 10⁻⁸	−0.90 ± 0.17	7.21 × 10⁻⁸
HbA1c	7524	0.003 ± 0.008	0.6858	0.006 ± 0.008	0.4870	0.004 ± 0.008	0.5924
Obesity
BMI	13,378	−0.16 ± 0.05	2.14 × 10⁻³	−0.16 ± 0.05	2.10 × 10⁻³	−0.13 ± 0.05	1.06 × 10⁻²
WHR	13,378	−0.005 ± 0.001	2.87 × 10⁻⁶	−0.005 ± 0.001	3.35 × 10⁻⁶	−0.004 ± 0.001	3.45 × 10⁻⁵

n number of participants, s.e. standard error, TG Triglyceride, TC Total cholesterol, LDL Low density lipoprotein cholesterol, HDL high density lipoprotein cholesterol, SBP systolic blood pressure, DBP diastolic blood pressure, FPG fasting plasma glucose, HbA1c Glycated hemoglobin, BMI body mass index, WHR waist-hip ratio
All of analyses were adjusted by age and sex

ISSN: 1475-2840