Evaluation of pleiotropic effects among common genetic loci identified for cardio-metabolic traits in a Korean population

Kim, Yun Kyoung; Hwang, Mi Yeong; Kim, Young Jin; Moon, Sanghoon; Han, Sohee; Kim, Bong-Jo

doi:10.1186/s12933-016-0337-1

Cardiovascular Diabetology

Table 1 Results of meta-analyses for associations between lipid loci and cardio-metabolic traits

From: Evaluation of pleiotropic effects among common genetic loci identified for cardio-metabolic traits in a Korean population

Category	Trait	CHR	SNP	Position	Gene	Function	A1/A2	MAF	Effect size (beta ± s.e.)	P _combined	P _het (Q)
Glycemic traits (n = 13,378)	FPG	2	rs780093	27742603	GCKR	Intronic	G/A	0.456	0.73 ± 0.13	6.26 × 10⁻⁹	0.72 (0.64)
		11	rs174547	61570783	FADS1	Intronic	G/A	0.319	−0.70 ± 0.13	1.71 × 10⁻⁷	0.94 (0.12)
		11	rs174570	61597212	FADS2	Intronic	A/G	0.319	−0.71 ± 0.13	1.09 × 10⁻⁷	0.97 (0.07)
		12	rs3782886	112110489	BRAP	Nonsynonymous	G/A	0.167	−0.90 ± 0.17	7.21 × 10⁻⁸	0.67 (0.79)
		12	rs11066015	112168009	ACAD10	Intronic	A/G	0.158	−0.92 ± 0.17	5.93 × 10⁻⁸	0.74 (0.60)
		12	rs671	112241766	ALDH2	Nonsynonymous	A/G	0.157	−0.96 ± 0.17	2.00 × 10⁻⁸	0.80 (0.44)
	HbA1c	6	rs1799945	26091179	HFE	Nonsynonymous	G/C	0.045	−0.06 ± 0.01	4.57 × 10⁻⁵	–
Blood pressure (n = 10,310)	SBP	12	rs3782886	112110489	BRAP	Nonsynonymous	G/A	0.167	−1.34 ± 0.31	1.50 × 10⁻⁵	0.04 (4.15)
		12	rs11066015	112168009	ACAD10	Intronic	A/G	0.158	−1.53 ± 0.32	1.33 × 10⁻⁶	0.03 (4.50)
		12	rs671	112241766	ALDH2	Nonsynonymous	A/G	0.157	−1.49 ± 0.32	2.72 × 10⁻⁶	0.05 (4.01)
	DBP	12	rs3782886	112110489	BRAP	Nonsynonymous	G/A	0.167	−0.78 ± 0.20	1.02 × 10⁻⁴	0.49 (0.48)
		12	rs11066015	112168009	ACAD10	Intronic	A/G	0.158	−0.82 ± 0.21	7.12 × 10⁻⁵	0.41 (0.67)
		12	rs671	112241766	ALDH2	Nonsynonymous	A/G	0.157	−0.80 ± 0.21	1.09 × 10⁻⁴	0.47 (0.52)
Obesity (n = 13,378)	BMI	16	rs1421085	53800954	FTO	Intronic	G/A	0.125	0.29 ± 0.06	1.84 × 10⁻⁷	0.70 (0.71)
	WHR	5	rs3846662	74651084	HMGCR	Intronic	A/G	0.476	0.003 ± 0.001	3.69 × 10⁻⁴	0.29 (2.45)
		12	rs3782886	112110489	BRAP	Nonsynonymous	G/A	0.167	−0.004 ± 0.001	3.45 × 10⁻⁵	0.12 (4.32)
		12	rs11066015	112168009	ACAD10	Intronic	A/G	0.158	−0.005 ± 0.001	3.35 × 10⁻⁶	0.13 (4.14)
		12	rs671	112241766	ALDH2	Nonsynonymous	A/G	0.157	−0.005 ± 0.001	2.87 × 10⁻⁶	0.13 (4.10)

A threshold of association significance after correction for multiple testing is P < 3.70 × 10⁻⁴
CHR chromosome, A1/A2 minor allele/major allele, MAF minor allele frequency, n number of participants, SBP systolic blood pressure, DBP diastolic blood pressure, FPG fasting plasma glucose, HbA1c Glycated hemoglobin, BMI body mass index, WHR waist-hip ratio; All of analyses were adjusted by age and sex. s.e. standard error, P _combined P value from meta-analyses using the results from three cohorts, P _het P value from test of heterogeneity, Q Cochrane’s Q value based on Chi squared statistics

Back to article page

ISSN: 1475-2840

Contact us

Submission enquiries: journalsubmissions@springernature.com