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Table 3 Incidence rate and hazard ratios (HR) for stroke and myocardial infarction depending on the CLOCK-rs4580704 in T2D subjects at baseline (n = 3427)

From: CLOCK gene variation is associated with incidence of type-2 diabetes and cardiovascular diseases in type-2 diabetic subjects: dietary modulation in the PREDIMED randomized trial

CLOCK genotypes Cases Person-y Incidence ratea Model 1 Model 2
HR 95 % CI P value HR 95 % CI P value
Stroke
 Dominant model
  CC 43 5780.3 7.4 1.00 (Reference)   1.00 (Reference)  
  CG + GG 43 9306.9 4.6 0.61 (0.40–0.93) 0.022 0.61 (0.40–0.94) 0.024
  P (interaction CLOCK × T2D status)    0.016    0.018
Myocardial infraction
 Dominant model
  CC 24 5479.4 4.4 1.00 (Reference)   1.00 (Reference)  
  CG + GG 40 9057.8 4.4 0.99 (0.60–1.65) 0.982 1.01 (0.61–1.70) 0.941
  P (interaction CLOCK × T2D status)    0.906    0.922
  1. Model 1: adjusted for sex, age, center and dietary intervention group
  2. Model 2: adjusted for variables in model 1 plus BMI, drinking, smoking, physical activity, medication (hypertension, dyslipemia and glucose), adherence to the Mediterranean Diet and total energy intake at baseline
  3. P for interaction terms between the CLOCK SNP (as dominant) with T2D in determining stroke or myocardial infarction were estimated in the corresponding multivariable models in the whole population
  4. aCrude incidence rates were expressed per 1000 person-years of follow-up