CLOCK gene variation is associated with incidence of type-2 diabetes and cardiovascular diseases in type-2 diabetic subjects: dietary modulation in the PREDIMED randomized trial

Table 3 Incidence rate and hazard ratios (HR) for stroke and myocardial infarction depending on the CLOCK-rs4580704 in T2D subjects at baseline (n = 3427)

CLOCK genotypes	Cases	Person-y	Incidence rate^a	Model 1			Model 2
CLOCK genotypes	Cases	Person-y	Incidence rate^a	HR	95 % CI	P value	HR	95 % CI	P value
Stroke
Dominant model
CC	43	5780.3	7.4	1.00	(Reference)		1.00	(Reference)
CG + GG	43	9306.9	4.6	0.61	(0.40–0.93)	0.022	0.61	(0.40–0.94)	0.024
P (interaction CLOCK × T2D status)						0.016			0.018
Myocardial infraction
Dominant model
CC	24	5479.4	4.4	1.00	(Reference)		1.00	(Reference)
CG + GG	40	9057.8	4.4	0.99	(0.60–1.65)	0.982	1.01	(0.61–1.70)	0.941
P (interaction CLOCK × T2D status)						0.906			0.922

Model 1: adjusted for sex, age, center and dietary intervention group
Model 2: adjusted for variables in model 1 plus BMI, drinking, smoking, physical activity, medication (hypertension, dyslipemia and glucose), adherence to the Mediterranean Diet and total energy intake at baseline
P for interaction terms between the CLOCK SNP (as dominant) with T2D in determining stroke or myocardial infarction were estimated in the corresponding multivariable models in the whole population
^aCrude incidence rates were expressed per 1000 person-years of follow-up