Skip to main content

Table 2 Incidence rate and hazard ratios (HR) for type-2 diabetes (T2D) depending on the CLOCK-rs4580704 in non-T2D subjects

From: CLOCK gene variation is associated with incidence of type-2 diabetes and cardiovascular diseases in type-2 diabetic subjects: dietary modulation in the PREDIMED randomized trial

CLOCK genotypes

Non-T2D subjects at baseline (n = 3671)

Cases

Person-y

Incidence ratea

Model 1

Model 2

HR

95 % CI

P value

HR

95 % CI

P value

Dominant model

 CC

130

6088.5

21.4

1.00

(Reference)

 

1.00

(Reference)

 

 CG + GG

156

10727.7

14.5

0.68

(0.54–0.86)

0.001

0.69

(0.54–0.87)

0.002

  1. Model 1: adjusted for sex, age, center and dietary intervention group
  2. Model 2: adjusted for variables in model 1 plus BMI, drinking, smoking, physical activity, medication (hypertension, dyslipemia and glucose), adherence to the Mediterranean Diet and total energy intake at baseline
  3. aCrude incidence rates were expressed per 1000 person-years of follow-up
Back to article page

Cardiovascular Diabetology

ISSN: 1475-2840