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Table 2 Incidence rate and hazard ratios (HR) for type-2 diabetes (T2D) depending on the CLOCK-rs4580704 in non-T2D subjects

From: CLOCK gene variation is associated with incidence of type-2 diabetes and cardiovascular diseases in type-2 diabetic subjects: dietary modulation in the PREDIMED randomized trial

CLOCK genotypes Non-T2D subjects at baseline (n = 3671)
Cases Person-y Incidence ratea Model 1 Model 2
HR 95 % CI P value HR 95 % CI P value
Dominant model
 CC 130 6088.5 21.4 1.00 (Reference)   1.00 (Reference)  
 CG + GG 156 10727.7 14.5 0.68 (0.54–0.86) 0.001 0.69 (0.54–0.87) 0.002
  1. Model 1: adjusted for sex, age, center and dietary intervention group
  2. Model 2: adjusted for variables in model 1 plus BMI, drinking, smoking, physical activity, medication (hypertension, dyslipemia and glucose), adherence to the Mediterranean Diet and total energy intake at baseline
  3. aCrude incidence rates were expressed per 1000 person-years of follow-up