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Table 2 Univariate correlations of parameters with serum betatrophin level in all participants, and T2DM patients with normoalbuminuria, microalbuminuria, and macroalbuminuria

From: Higher serum betatrophin level in type 2 diabetes subjects is associated with urinary albumin excretion and renal function

Parameters

All participants r (P value)

Healthy r (P value)

Normoalbuminuria r (P value)

Microalbuminuria r (P value)

Macroalbuminuria r (P value)

Age (years)

0.131 (0.145)

−0.108 (0.960)

−0.123 (0.476)

0.278 (0.145)

−0.362 (0.033*)

Sex (Male/Female)

−0.331 (<0.001*)

−0.485 (0.008*)

0.086 (0.625)

−0.530 (0.003*)

−0.278 (0.105)

DM duration (years)

0.385 (<0.001*)

0.183 (0.292)

−0.392 (0.035*)

0.009 (0.960)

SBP (mmHg)

0.194 (0.032*)

0.113 (0.583)

0.040 (0.821)

0.104 (0.592)

−0.166 (0.342)

DBP (mmHg)

0.141 (0.122)

−0.012 (0.955)

0.167 (0.346)

0.281 (0.140)

−0.324 (0.057)

BMI (kg/m2)

0.194 (0.031*)

0.010 (0.961)

0.105 (0.550)

0.025 (0.897)

0.192 (0.269)

FBG (mg/dL)

0.175 (0.048*)

−0.002 (0.993)

−0.040 (0.819)

0.357 (0.045*)

−0.076 (0.663)

ACR (mg/g)

0.427 (<0.001*)

−0.180 (0.359)

0.342 (0.042*)

0.343 (0.049*)

0.025 (0.890)

eGFR (ml/min/1.73 m2)

−0.454 (<0.001*)

−0.108 (0.578)

−0.375 (0.024*)

−0.435 (0.018*)

−0.239 (0.166)

HbA1c (%)

0.264 (0.003*)

0.169 (0.380)

0.289 (0.077)

0.361 (0.045*)

−0.127 (0.469)

hsCRP (mg/dL)

0.133 (0.138)

−0.108 (0.578)

0.009 (0.959)

−0.208 (0.278)

−0.135 (0.438)

Triglyceride (mg/dL)

0.282 (0.001*)

0.184 (0.338)

−0.222 (0.200)

0.368 (0.042*)

0.224 (0.196)

Total Cholesterol (mg/dL)

−0.261 (0.001*)

0.102 (0.599)

0.176 (0.313)

−0.434 (0.019*)

−0.192 (0.270)

LDL cholesterol (mg/dL)

0.017 (0.853)

0.027 (0.889)

0.236 (0.172)

−0.278 (0.144)

−0.027 (0.880)

HDL cholesterol (md/dL)

−0.391 (<0.001*)

−0.293 (0.130)

0.132 (0.449)

−0.593 (<0.001*)

−0.446 (0.007*)

  1. SBP systolic blood pressure, DBP diastolic blood pressure, BMI body mass index, FBG fasting blood glucose, ACR albumin /creatinine ratio, eGFR estimated glomerular filtration rate, HbA1c hemoglobin A1c, hsCRP high sensitive C-reactive protein, r coefficient correlation
  2. * P value <0.05 significant correlation as assessed by Spearman’s correlation method