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Fig. 6 | Cardiovascular Diabetology

Fig. 6

From: Polydatin ameliorates lipid and glucose metabolism in type 2 diabetes mellitus by downregulating proprotein convertase subtilisin/kexin type 9 (PCSK9)

Fig. 6

Molecular docking revealed a direct combination between polydatin and PCSK9 crystal structure (PDB code: 2p4e). a The chemical structure of polydatin, which contained several phenolic hydroxyl groups. b Docking pose of polydatin in the active pocket of the PCSK9 crystal structure. c Polydatin formed steady hydrogen bonds with PCSK9 in several amino residues consisting of Cys358, Val435, Asn439, and Asp651. Key residues are shown in stick representation. Carbon, oxygen, and hydrogen for the polydatin are colored yellow, red, and silver, respectively

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Cardiovascular Diabetology

ISSN: 1475-2840