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Table 3 Mortality during follow-up by history of LEA at baseline

From: Lower-extremity amputation as a marker for renal and cardiovascular events and mortality in patients with long standing type 1 diabetes

  All-cause mortality Cardiovascular mortality Infectious disease mortality Other causes of mortality
No Yes No Yes No Yes No Yes
LEA at baseline
 No 691 (93.6 %) 47 (6.4 %) 691 (97.5 %) 18 (2.5 %) 691 (99.0 %) 7 (1.0 %) 691 (96.9 %) 22 (3.1 %)
 Yes 36 (59.0 %) 25 (41.0 %) 36 (78.3 %) 10 (21.7 %) 36 (92.3 %) 3 (7.7 %) 36 (75.0 %) 12 (25.0 %)
HR (95 % CI) model 1 3.55 (2.05–6.16) 4.04 (1.69–9.62) 3.28 (0.73 –14.68) 3.25 (1.44–7.30)
P <0.0001 0.002 0.12 0.004
HR (95 % CI) model 2 2.73 (1.49–5.01) 3.30 (1.36–8.02) 5.18 (1.13–23.84) 2.81 (1.09–7.26)
P 0.001 0.008 0.03 0.03
  1. Data expressed as number of cases and (%) by line. Hazards ratio (HR) for a positive LEA history at baseline as a risk for all-cause mortality, cardiovascular, infectious disease, and other causes of mortality during follow-up, computed by Cox proportional hazards survival regressive analysis. Model 1: adjusted for cohort membership, sex and age at baseline. Model 2: adjusted for cohort membership, sex, age, duration of diabetes, HbA1c, UAC, eGFR, use of antihypertensive and lipids lowering drugs, and history of tobacco smoking
  2. p < 0.05 is significant