Table 2 Changes at 36 months from baseline

Glucose fasting (mg/dl)

−7 [−12] ± 52 [53]

0.375 [0.095]

−17 [−19] ± 42 [44]

0.021 [0.008]

0.336 [0.510]

Glucose pp (mg/dl)

−20 [−20] ± 62 [64]

0.038 [0.021]

9 [4] ± 53 [56]

0.335 [0.676]

0.032 [0.047]

HbA1c (%)

−0.4 [−0.6] ± 1.5 [1.7]

0.063 [0.011]

−1.3 [−1.2] ± 1.8 [1.7]

0.000 [0.000]

0.024 [0.082]

Intact proinsulin^a (pmol/l)

−0.9 {−2.3 to 0.8}

0.171

0.3 {−0.9 to 2.7}

0.199

0.048

Triglycerides (mg/dl)

0 [1] {−12 [−18] to 33 [34]}

0.496 [0.577]

11 [8] {6 [−15] to 41 [41]}

0.016 [0.167]

0.153 [0.467]

Triglycerides pp (mg/dl)

10 [9] {−15 [−22] to 39 [45]}

0.081 [0.198]

24 [17] {−4 [−10] to 64 [55]}

0.023 [0.040]

0.317 [0.424]

Cholesterol (mg/dl)

10 [10] ± 49 [50]

0.161 [0.186]

6 [6] ± 43 [42]

0.437 [0.375]

0.668 [0.699]

LDL (mg/dl)

5 [3] ± 40 [43]

0.420 [0.685]

−7 [−5] ± 39 [38]

0.262 [0.408]

0.170 [0.367]

HDL (mg/dl)

1 [0] {−3 [−5] to 4 [5]}

0.636 [0.628]

2 [1] {−6 [−6] to 9 [9]}

0.493 [0.487]

0.844 [0.668]

Creatinine (mg/dl)

0 [0] {−0.10 [−0.10] to 0.10 [0.10]}

0.954 [0.710]

0.10 [0.09] {0 [−0.03] to 0.10 [0.15]}

0.018 [0.009]

0.054 [0.064]

ASAT U/l

−2 [−1] {−7 [−11] to 3 [6]}

0.096 [0.400]

1 [1] {−4 [−11] to 10 [11]}

0.586 [0.734]

0.126 [0.554]

hsCRP (mg/dl)

0 [−0.01] {−0.18 [−0.24] to 0.1 [0.14]}

0.468 [0.521]

0.05 [0.01] {−0.1 [−0.19] to 0.15 [0.18]}

0.307 [0.669]

0.199 [0.525]

LV enddiast. diameter (mm)

2 [2] {−2 [−2] to 6 [5]}

0.041 [0.032]

1 [1] {0 [−1] to 3 [3]}

0.149 [0.151]

0.387 [0.395]

Septal thickness (mm)

0 [−0.1] {−2 [−1.4] to 2 [2]}

0.948 [0.733]

0 [0] {−2 [−1.6] to 1 [1.7]}

0.718 [0.706]

0.768 [0.722]

Post. wall thickness (mm)

1 [0.8] {−1 [−0.9] to 2 [1.4]}

0.103 [0.082]

1 [0.9] {0 [−0.4] to 2 [2]}

0.010 [0.012]

0.388 [0.501]

S’ (cm/s)

0 [0] ± 0.8 [0.8]

0.889 [0.801]

0.1 [0.1] ± 1 [0.9]

0.504 [0.571]

0.516 [0.753]

E’ (cm/s)

0.4 [0.5] ± 1.4 [1.4]

0.069 [0.013]

0.1 [0] ± 1.3 [1.3]

0.738 [0.853]

0.312 [0.059]

E’ pp (cm/s)

0.6 [0.6] ± 1.4 [1.4]

0.009 [0.002]

0.2 [0.1] ± 1.4 [1.5]

0.435 [0.430]

0.241 [0.110]

E/E’ (mmHg)

−0.1 [−0.01] {−1.52 [−1.54] to 1.54 [1.46]}

0.870 [0.657]

0.35 [0.25] {−0.9 [−1.02] to 1.99 [1.98]}

0.136 [0.182]

0.192 [0.198]

IMT (mm)

0.03 [0.05] ± 0.17 [0.18]

0.200 [0.048]

0.06 [0.07] ± 0.19 [0.18]

0.091 [0.018]

0.551 [0.649]

Elasticity modulus (kPa)

15 [8] {−36 [−40] to 49 [60]}

0.363 [0.463]

30 [8] {−41 [−65] to 78 [68]}

0.313 [0.622]

0.643 [0.740]

PWV (m/s)

0.2 [0.1] {−0.9 [−0.9] to 0.9 [1.1]}

0.684 [0.494]

0.5 [0] {−1 [−1.4] to 1.7 [1.4]}

0.319 [0.622]

0.448 [0.693]

Heart rate (bpm)

−4 [−4] {−10 [−10] to 5 [4]}

0.057 [0.026]

−4 [−4] {−7 [−7] to 3 [3]}

0.026 [0.079]

0.920 [0.630]

Systolic BP (mmHg)

3 [7] {−9 [−9] to 20 [20]}

0.175 [0.087]

20 [17] {−5 [−4] to 29 [29]}

0.008 [0.002]

0.065 [0.075]

Diastolic BP (mmHg)

5 [5] ± 12 [12]

0.005 [0.003]

10 [11] ± 12 [12]

0.000 [0.000]

0.062 [0.064]