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Fig. 5 | Cardiovascular Diabetology

Fig. 5

From: Insulin treatment increases myocardial ceramide accumulation and disrupts cardiometabolic function

Fig. 5

Chronic insulin injections increase blood insulin and induce glucose and insulin intolerance. 16-week-old male mice received injections of PBS (daily), insulin (INS; daily; 0.75 mg/kg), myriocin (MYR, thrice weekly; 3 mg/kg), or INS + MYR. Blood insulin (a) and glucose (b) was tracked weekly. At the conclusion of the study, IP glucose (c) and insulin (d) tolerance tests were performed. *P < 0.05 for INS vs. PBS; #P < 0.05 for INS + MYR vs. INS alone

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