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Fig. 1 | Cardiovascular Diabetology

Fig. 1

From: Insulin treatment increases myocardial ceramide accumulation and disrupts cardiometabolic function

Fig. 1

Insulin increases ceramide in cardiomyocytes. H9C2 cardiomyocytes were treated with insulin (INS; 50 nM) with or without myriocin (MYR; 10 μM), an inhibitor of ceramide biosynthesis, for the times indicated (n = 6). Following treatment time, lipids were isolated for analysis of sphingolipids via LCMS (a; n = 6) and protein levels of ceramide biosynthetic enzymes determined (b; n = 4). *P < 0.05 for INS vs. other treatments

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