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Table 4 Cardiac expression levels of genes involved in endothelial activation, inflammation, metabolism and cardiac hypertrophy in control and HFD rats after 6 weeks of high fat diet feeding

From: Early impairment of coronary microvascular perfusion capacity in rats on a high fat diet

 

Control (N = 8)

HFD (N = 9)

P value

Endothelial activation

 ICAM

1.0 ± 0.19

0.67 ± 0.13

0.13

 VCAM

1.0 ± 0.22

0.79 ± 0.14

0.43

 eNOS

1.0 ± 0.17

0.86 ± 0.14

0.52

Inflammation

 MCP1

1.0 ± 0.26

1.08 ± 0.41

0.88

 CD68

1.0 ± 0.25

0.65 ± 0.07

0.17

Metabolism

 PDK4

1.0 ± 0.17

1.94 ± 0.51

0.11

 Angptl4

1.0 ± 0.35

1.13 ± 0.31

0.79

Hypertrophy

 ANF

1.0 ± 0.39

0.45 ± 0.26

0.25

 αSKA

1.0 ± 0.24

1.36 ± 0.42

0.49

  1. Data are expressed relative to control rats (chow) as mean ± SEM
  2. * p < 0.05
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Cardiovascular Diabetology

ISSN: 1475-2840