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Fig. 6 | Cardiovascular Diabetology

Fig. 6

From: The soluble guanylate cyclase activator cinaciguat prevents cardiac dysfunction in a rat model of type-1 diabetes mellitus

Fig. 6

Effect of cinaciguat on left ventricular (LV) contractility and cardiac stiffness in diabetes mellitus. a Representative pressure–volume (P–V) loops, b preload recruitable stroke work (PRSW) (P value of diabetes × treatment interaction in the two-factorial ANOVA, Pinteraction = 0.003), slope (Ees) of LV end-systolic P–V relationship (Pinteraction = 0.006) and the slope of LV end-diastolic P–V relationship (EDPVR) (Pinteraction = 0.004) are presented in vehicle-treated control (Co), cinaciguat-treated control (CoCin), vehicle-treated diabetic (DiabCo) and cinaciguat-treated diabetic (DiabCin) groups. Bar graphs represent mean ± SEM of 9–11 experiments per group. *P < 0.05 vs. Co, P < 0.05 vs. DiabCo (Tukey HSD test)

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