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Fig. 6 | Cardiovascular Diabetology

Fig. 6

From: Glucose and fatty acid metabolism in infarcted heart from streptozotocin-induced diabetic rats after 2 weeks of tissue remodeling

Fig. 6

Diabetes is an ischemic preconditioning-like state by increasing the HIF-1α expression, leading to angiogenesis and modulating key metabolic pathways to optimize glucosea. After myocardial infarction, this heart is conditioned to increase the expression of glucose transporter 1 (Glut-1)a, activating glycolysis and FFA uptake (CPT1-M)b. The O2 utilization in hypoxia to generate sufficient amounts of ATP without producing excessive amounts of ROSc, which would inhibit tricarboxylic acid cycle and mitochondrial respiration, promotes a positive remodeling, thus preserving the left ventricular function. a [7]; b present data; c [8]

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