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Table 2 Clinical parameter comparisons between baseline and post

From: Effect of metformin monotherapy on cardiovascular diseases and mortality: a retrospective cohort study on Chinese type 2 diabetes mellitus patients

Clinical parameters (Mean ± SD) Full cohort with complete case Propensity score-matched cohort
MM group paired diff.a (N = 7493) Control group paired diff.a (N = 3800) Diff. in diff. (MM group—control group) P value MM group paired diff.a (N = 3400) Control group paired diff.a (N = 3400) Diff. in diff. (MM group—control group) P value
HbA1c, % −0.04 ± 1.08 0.29 ± 0.68 −0.32 <0.001* 0.19 ± 0.79 0.28 ± 0.69 −0.09 <0.001*
SBP, mmHg −2.86 ± 19.33 −1.91 ± 19.04 −0.95 0.013* −3.07 ± 19.40 −1.95 ± 18.95 −1.12 0.016*
DBP, mmHg −2.20 ± 10.64 −1.42 ± 10.16 −0.78 <0.001* −2.25 ± 10.54 −1.30 ± 10.15 −0.95 <0.001*
LDL-C, mmol/L −0.58 ± 0.90 −0.48 ± 0.89 −0.10 <0.001* −0.71 ± 0.92 −0.44 ± 0.87 −0.27 <0.001*
TC/HDL-C ratio −0.69 ± 1.04 −0.60 ± 1.22 −0.09 <0.001* −0.78 ± 1.07 −0.56 ± 1.01 −0.23 <0.001*
Triglyceride, mmol/L −0.21 ± 0.84 −0.14 ± 0.75 −0.07 <0.001* −0.18 ± 0.73 −0.14 ± 0.77 −0.03 0.059
BMI, kg/m2 −0.30 ± 1.55 −0.05 ± 1.46 −0.25 <0.001* −0.19 ± 1.54 −0.08 ± 1.43 −0.11 0.002*
  1. MM metformin monotherapy, HbA1c haemoglobin A1c, SBP systolic blood pressure, DBP diastolic blood pressure, LDL-C low density lipoprotein-cholesterol, TC total cholesterol, HDL-C high density lipoprotein-cholesterol, BMI body mass index, DM diabetes mellitus
  2. * Significant with p value <0.05 by independent t test
  3. aPaired difference (Post—baseline)