Fig. 7
From: SIRT1 protects against myocardial ischemia–reperfusion injury via activating eNOS in diabetic rats
NOS inhibitor L-NAME inhibited cardioprotective effects of Ad-SIRT1. a eNOS activity, b Top representative blot images. Bottom quantitative analysis of phosphorylated eNOS (p-eNOS); c Top representative blot images. Bottom quantitative analysis of acetylated eNOS (Ac-eNOS); d Myocardial infarct size expressed as a percent of infarct area (INF) over total area at risk (AAR); e Myocardial caspase-3 activity; f Cardiac superoxide generation. DIR, diabetic I/R rats receiving Ad-GFP; Ad.SIRT1, diabetic I/R rats receiving Ad-SIRT1; Ad.SIRT1 + L-NAME, diabetic I/R rats receiving Ad-SIRT1 and L-NAME. Values are mean ± SEM. n = 4–6. *P < 0.05, **P < 0.01 vs. DIR; # P < 0.05, ## P < 0.01 vs. Ad.SIRT1