Fig. 4
From: SIRT1 protects against myocardial ischemia–reperfusion injury via activating eNOS in diabetic rats
Up-regulation of SIRT1 inhibited cardiomyocyte apoptosis in diabetic hearts subjected to I/R. a Top Representative photomicrographs of TUNEL-positive apoptotic cardiomyocytes in the area at risk following MI/R (original magnification ×400). Bottom Quantitative analysis of myocardial apoptosis. b Myocardial caspase-3 activity. NS, non-diabetic sham rats; NIR, non-diabetic I/R rats receiving Ad-GFP; DS, diabetic sham rats; DIR, diabetic I/R rats receiving Ad-GFP; Ad.SIRT1, diabetic I/R rats receiving Ad-SIRT1. Values are mean ± SEM. n = 8. **P < 0.01 vs. NS; ## P < 0.01 vs. NIR; τ P < 0.05, ττ P < 0.01 vs. DIR