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Fig. 6 | Cardiovascular Diabetology

Fig. 6

From: Corin is down-regulated and exerts cardioprotective action via activating pro-atrial natriuretic peptide pathway in diabetic cardiomyopathy

Fig. 6

Defect of corin was associated with endothelial dysfunction. a The wound healing scratch assay showed the effect of culture supernatants of H9c2 cardiomyoblasts transfected Corin-siRNA or NC-siRNA on EA.hy926 cells migration at 0 and 24 h. Bar 250 μm. b, c Reduced capillary and arteriole densities in DCM rat myocardium were detected by confocal fluorescence microscope. Capillary and arteriole densities were stained by iso-lectin B4 (green) in rat hearts, nuclei were stained with Dapi (blue). Bar 50 μm (n = 5 to 6 rats for each group). For quantification, 4 or 5 randomly selected fields from each rat myocardial tissue under ×400 magnification were analyzed. Data are presented as mean ± SD. *P < 0.05 versus Ctrl

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Cardiovascular Diabetology

ISSN: 1475-2840