|
Men
|
Baseline (n = 71)
|
1st year (n = 69)
|
2nd year (n = 69)
|
3rd year (n = 69)
|
p
|
|---|
|
Vascular
|
|
C-IMT average (mm)¶
|
0.779 ± 0.127
|
0.776 ± 0.123
|
0.769 ± 0.123
|
0.796 ± 0.126
|
0.005
|
|
Plaques carotid n (%)
|
16 (23.2)
|
15 (21.7)
|
19 (27.5)
|
21 (30.4)
|
0.148
|
|
ABI*
|
1.15 ± 0.11
|
1.19 ± 0.12
|
1.18 ± 0.13
|
1.16 ± 0.11
|
<0.001
|
|
PWV (m/s)
|
9.31 ± 2.32
|
9.33 ± 2.64
|
9.68 ± 2.37
|
9.48 ± 2.47
|
0.661
|
|
Renal
|
|
Serum creatinine (mg/dL)
|
0.95 ± 0.14
|
0.97 ± 0.18
|
0.93 ± 0.17
|
0.96 ± 0.18
|
0.110
|
|
eGFR (mL/min/1.73 m2)
|
89.5 ± 16.8
|
88.5 ± 18.3
|
92.3 ± 19.8
|
87.9 ± 18.2
|
0.072
|
|
Albumin/creatinine ratio (mg/g)
|
34.8 ± 81.4
|
44.0 ± 122.9
|
37.7 ± 113.8
|
45.9 ± 156.8
|
0.826
|
|
Heart
|
|
Cornell VDP (mm/ms)
|
1487 ± 573
|
1538 ± 506
|
1515 ± 543
|
1458 ± 535
|
0.285
|
|
Sokolow (mm/ms)*§||
|
20.3 ± 5.9
|
18.7 ± 6.2
|
21.3 ± 6.6
|
20.4 ± 6.8
|
<0.001
|
|
Women
|
Baseline (n = 41)
|
1st year (n = 41)
|
2nd year (n = 41)
|
3rd year (n = 41)
|
p
|
|---|
|
Vascular
| | | | |
|
C-MT average (mm)§
|
0.715 ± 0.092
|
0.728 ± 0.076
|
0.726 ± 0.099
|
0.754 ± 0.115
|
0.034
|
|
Plaques carotid, n (%)†§
|
3 (7.3)
|
3 (7.3)
|
6 (14.6)
|
11 (26.8)
|
<0.001
|
|
ABI*†‡
|
1.07 ± 0.10
|
1.17 ± 0.09
|
1.18 ± 0.10
|
1.14 ± 0.09
|
<0.001
|
|
PWV (m/s)
|
9.74 ± 2.70
|
9.21 ± 2.11
|
9.14 ± 2.34
|
9.79 ± 2.92
|
0.286
|
|
Renal
|
|
Serum creatinine (mg/dL)
|
0.73 ± 0.11
|
0.73 ± 0.12
|
0.70 ± 0.13
|
0.72 ± 0.14
|
0.285
|
|
eGFR (mL/min/1.73 m2)
|
89.1 ± 16.6
|
93.2 ± 22.6
|
95.0 ± 16.6
|
93.1 ± 22.1
|
0.163
|
|
Albumin/creatinine ratio (mg/g)
|
14.6 ± 37.4
|
6.6 ± 6.6
|
3.0 ± 5.6
|
9.1 ± 14.8
|
0.122
|
|
Heart
|
|
Cornell VDP (mm/ms)
|
1741 ± 598
|
1756 ± 542
|
1852 ± 680
|
1838 ± 740
|
0.430
|
|
Sokolow (mm/ms)§
|
19.1 ± 6.1
|
19.4 ± 5.3
|
20.5 ± 5.6
|
19.6 ± 5.7
|
0.013
|
- Data for qualitative variables are expressed as n: number and (%) and quantitative variables as mean ± standard deviation
-
C Carotid, IMT intima media thickness carotid, ABI ankle brachial index, PWV pulse wave velocity, eGFR estimated glomerular filtration rate, Cornell VDP cornell voltage duration product
- p < 0.05: between * baseline and 1st year; †baseline and 2nd year; ‡baseline and 3rd year
- p < 0.05: between §1st and 2nd year; ||1st and 3rd year
- p < 0.05 between ¶2nd and 3rd year
